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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 457 - 463 (7page)
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The sex steroid hormone estradiol-17β(E2) mediate their biological effects on development, differentiation and maintenance of reproductive tract and other target tissue through gene regulation by nuclear steroid receptors. Although the importance of E2 in many physiological process has been reported, but little is known about the effects of E2 on primary cultured chicken hepatocyte. therefore, in the present study, we have examined the effect of E2 on cell proliferation and it`s related signal cascades. E2 increase [3H]-thymidine incorporation in time-(≤8hr) and dose-(10-10M)dependent manner and treatment of E2 increased the phos-phorylation of p44/43 MAPKs(p44/42 mitogen-activated protein kinase) and JNK(c-Jun N-terminal kinase) in a time dependent manner. In addition, PD98059(p44/42 blocker, 10-5 M), SP600125(JNK blocker, 10-6M) blocked the estrogen-induced increase in [3H]-thymidine incorporation. In conclusion, E2 stimulates the proliferation of primary cultured chicken hepatocytes and this action is mediated by p44/42 MAPKs and JNK signal transduction pathway.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Brett CM / 1993 / Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney / Pharm Res 10 : 423 ~
Dent P / 2003 / MAPK pathways in radiation responses / Oncogene 22 : 5885 ~ 5896
Edwards DP / 2005 / Regulation of signal transduction pathways by estrogen and progesterone / Annu Rev Physiol 67 : 335 ~ 376
Fisher B / 1984 / Relation of estrogen and its receptor to rat liver growth and regeneration / Cancer Res 44 : 2410 ~ 2415
Francavilla A / 1989 / The effect of estrogen and tamoxifen on hepatocyte proliferation in vivo and in vitro / Hepatology 9 : 614 ~ 620
Dent P / 2003 / MAPK pathways in radiation responses / Oncogene 22 : 5885 ~ 5896
Edwards DP / 2005 / Regulation of signal transduction pathways by estrogen and progesterone / Annu Rev Physiol 67 : 335 ~ 376
Fisher B / 1984 / Relation of estrogen and its receptor to rat liver growth and regeneration / Cancer Res 44 : 2410 ~ 2415
Francavilla A / 1989 / The effect of estrogen and tamoxifen on hepatocyte proliferation in vivo and in vitro / Hepatology 9 : 614 ~ 620
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