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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 45 - 52 (8page)
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Single and repeated-dose toxicities of anti-hypertension herb extract microcapsule (AHHEM) were evaluated according to Toxicity Test Guidelines of Korea Food and Drug Administration using Sprague-Dawley rats. For single-dose toxicity test, kneading AHHEM with sterilized water were administered orally once at dose levels of 0 and 2,000 ㎎/㎏ and examined for 14 days. No dead animals, clinical signs and abnormal necropsy findings were observed and also no significant difference in body weights was found. Therefore, the median lethal dose (LD??) of AHHEM was considered to be higher than 2,000 ㎎/㎏ in both male and female rats. For repeated-dose toxicity test, AHHEM were mixed with powder fodder and administerd orally for 28 days at dose levels of 0, 500, 1,000 and 2,000 ㎎/㎏/day. No dead animals, clinical signs and significant difference in body weights were found. In hematology, mean corpuscular hemoglobin was increased in all doses of male groups, but which was not considered as a toxicological change considering the normal ranges of red blood cell count and hemoglobin concentration. In serum biochemistry, all values were included in the normal ranges. In histopathological examinations, any dose-dependant histopathological changes caused by AHHEM were not found. Therefore, the no observed adverse effect level (NOAEL) of AHHEM was considered to be higher than 2,000 ㎎/㎏ in both male and female rats.
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참고문헌
참고문헌 (8)
참고문헌 신청
Byeong, H.J , 1999 , Effect of saponin and non-saponin of Panax ginseng on the blood pressure in the renovascular hypertension rats 23 (2) : 81 ~ 87
Farrar, P.L , 1997 , Diagnostic exercise: interstitial pneumonia in viral and mycoplasmal antibody-free Sprague Dawley rats 18 (1) : 101 ~ 107
Greaves, P , 2000 , Histopathology of Preclinical Toxicity Studies; Interpretation and Relevance in Drug Evaluation
Han, C.K , 1996 , Effect of Antihypertensive diets mainly consisting of buckwheat, potato, and perilla seed on blood pressures and lipids in normotensive and spontaneously hypertensive rats 29 (10) : 1087 ~ 1095
J.L , 1993 , Rapidly progressive interstitial renal fibrosis in young women association with slimming regimen including Chinese herbs.Lancet 341 : 387 ~ 391
Farrar, P.L , 1997 , Diagnostic exercise: interstitial pneumonia in viral and mycoplasmal antibody-free Sprague Dawley rats 18 (1) : 101 ~ 107
Greaves, P , 2000 , Histopathology of Preclinical Toxicity Studies; Interpretation and Relevance in Drug Evaluation
Han, C.K , 1996 , Effect of Antihypertensive diets mainly consisting of buckwheat, potato, and perilla seed on blood pressures and lipids in normotensive and spontaneously hypertensive rats 29 (10) : 1087 ~ 1095
J.L , 1993 , Rapidly progressive interstitial renal fibrosis in young women association with slimming regimen including Chinese herbs.Lancet 341 : 387 ~ 391
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