지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.3
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
The purpose of this study is to investigate a potential toxicity of licorice root (LR) in Fisher 344 rats through the 13-week repeated oral treatment. Healthy Fisher 344 rats were divided into five treatment groups (2,000, 571, 163, 47, and 13 ㎎/㎏) and one control group (vehicle) of 12 males and 12 females respectively. LR was orally administered by gavage to F344 rats once a day, 5 days per week for 13 weeks. During the test period, clinical signs, mortality, body weights, necropsy findings, hematology, serum biochemistry, organ weight, histopathology, sperm count and sperm motility were evaluated. The relative liver weights were increased significantly in males of the 2,000 and 571 ㎎/㎏ groups. However, there was no histological evidence in the liver. The increased incidence of chronic nephropathy only appeared in the 2,000 ㎎/㎏ group of both male and female rats. There were no treatment-related effects on clinical signs, mortality, body weights, necropsy findings, hematology, serum biochemistry and sperm count and motility in any treatment groups. Based on these results, no-observed adverse effect level (NOAEL) of LR was 571 ㎎/㎏ in F344 rats under the conditions of the present study.
목차
Materials and Methods
Results
Discussion
Acknowledgment
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Subacute Toxicity Study of CS682, a Fermentation Product of Korean Soil Bacteria, in Rats
Laboratory Animal Research
2009 .03
-
Toxicity Study of AS6, a Triterpenoid Derivative: 4-Week Repeated Oral Administration in Rats
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2003 .01
-
A 4-week Repeated Oral Dose Toxicity Study of Plant Sterol Esters in Sprague-Dawley Rats
Toxicological Research
2002 .03
-
4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
Laboratory Animal Research
2013 .03
-
삼정환의 랫드를 이용한 90일 반복 경구투여 독성시험
한방비만학회지
2018 .01
-
14 Days Repeat Oral Dose Toxicity of Low Molecular Weight Fucoidan in Rats
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
-
A 4-week Repeated Oral Dose Toxicity Study of CJ-10882 in Dogs
Toxicological Research
2002 .09
-
Sprague-Dawley계 흰쥐를 이용한 HT042의 14일 반복 경구투여 독성연구
대한본초학회지(본초분과학회지)
2017 .01
-
Single Oral Dose Toxicity Evaluation of CS682, a Fermentation Product of Korean Soil Bacteria, in Rats
Laboratory Animal Research
2007 .12
-
Single and Four-Week Repeated Oral Toxicity Study of Anti-hypertension Herb Extract Microcapsule in Sprague-Dawely Rats
Laboratory Animal Research
2007 .03
-
Sprague-Dawley(SD) 랫드를 이용한 2주와 4주 반복투여 독성시험에 대한 혈액, 혈액생화학 및 장기중량 기초자료
Laboratory Animal Research
2004 .06
-
Study on a 4-Week Recovery Test of Sweet Bee Venom after a 13-Week, Repeated, Intramuscular Dose Toxicity Test in Sprague-Dawley Rats
Journal of Pharmacopuncture
2014 .01
-
Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies
Laboratory Animal Research
2010 .06
-
Toxicological Study of Safflower Seeds by Thirteen-Week Repeated Oral Administration in F344 Rats
Laboratory Animal Research
2008 .12
-
GST의 Sprague-Dawley Rat를 이용한 단회 경구투여 독성시험 및 4주 반복 경구투여 용량결정시험
대한한방내과학회지
2013 .01
-
Difructose Dianhydrides(DFA IV)의 랫드를 이용한 단회 및 4주간 반복 경구투여 독성시험
Toxicological Research
2004 .09
-
Spermatotoxic effects of α-chlorohydrin in rats
Laboratory Animal Research
2012 .03
-
산약(山藥)이 정자 운동성 저하에 미치는 영향
대한한의학방제학회지
2006 .01
-
랫드에서 이황화메틸의 2주 반복투여 흡입독성연구
Toxicological Research
2004 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Repeated dose 90-day oral toxicity of 20nm, positive charged Zinc Oxide Nanoparticles in SD rats
Nak-Won Seong
,
Eun-Ho Maeng
,
Su-Hyun Kim
외 11명
한국실험동물학회 학술발표대회 논문집
2013
.02
4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
Wook-Joon Yu
,
In-Chul Lee
,
Jinsoo Lee
외 7명
Laboratory Animal Research
2013
.03
국가연구개발사업의 표준특허 성과 검증 및 활용에 관한 연구
라유선
,
김대중
한국통신학회 학술대회논문집
2018
.06
Thirteen-week Repeated Oral Dose Toxicity Study of EstroG-200 in Sprague-Dawley Rats
Jun-Hwan Moon
,
Nam-Jin Lee
,
Bo-Yeon Kwak
외 5명
Laboratory Animal Research
2009
.12
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-510-016362676