지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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A 12-week repeated-dose oral toxicity study of water-soluble Orostachys japonicus extract (WOJ) was performed in Sprague-Dawley (SD) rats of both genders. Each group of ten rats was orally administered in doses of either 0 or 250 mg/day over a 12-week period. As a result, no WOJ-related changes were observed in terms of survival rate, clinical signs, body weight, or food intake. In addition, no difference in organ weight between the control and treated groups was detected. Furthermore, serum biochemistry parameters revealed some changes within normal ranges although significant decreases in total-bilirubin in the females. In spite of some alterations in serum biochemistry, the clinical signs, body weight changes from food intake, and autoptical remarks indicated that WOJ was not toxic. This study suggests that repeated treatment of O. japonicus very low toxicity and the NOAEL (no observed adverse effect dose) of WOJ exceeds 250 mg/kg in the SD rats.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
Acknowledgements
REFERENCES
참고문헌 (13)
참고문헌 신청
Jae-Han Jeong / 2011 / Anti-inflammatory effects of ethanol extract from Orostachys japonicus on modulation of signal pathways in LPS-stimulated RAW 264.7 cells / BMB Reports 44(6):399~404
Kim YS / 2010 / Subchronic oral toxicity of silver nanoparticles / PARTICLE AND FIBRE TOXICOLOGY 7
Lagarto A / 2011 / Acute and subchronic oral toxicities of Calendula officinalis extract in Wistar rats / Exp Toxicol Pathol 63:387~391
Ma CJ / 2009 / Calpain inhibitory flavonoids isolated from Orostachys japonicus / JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 24(3):676~679
Mei N / 2006 / DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver / Mutat Res 602:83~91
Kim YS / 2010 / Subchronic oral toxicity of silver nanoparticles / PARTICLE AND FIBRE TOXICOLOGY 7
Lagarto A / 2011 / Acute and subchronic oral toxicities of Calendula officinalis extract in Wistar rats / Exp Toxicol Pathol 63:387~391
Ma CJ / 2009 / Calpain inhibitory flavonoids isolated from Orostachys japonicus / JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 24(3):676~679
Mei N / 2006 / DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver / Mutat Res 602:83~91
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UCI(KEPA) : I410-ECN-0101-2013-510-001743915