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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.3
- 수록면
- 7 - 13 (7page)
이용수
초록· 키워드
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The present study was carried out to investigate the potential subacute toxicity of CS682, a fermentation product of Korean soil bacteria, by 3-week repeated oral administration in Sprague-Dawley rats. The test substance was administered once daily by gavage to male and female rats at dose levels of 0,100, 300, and 1,000 ㎎/㎏/day for 3 weeks. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weights, and histopathology were examined. Throughout the study period, no treatment-related deaths were observed. There were no treatment-related effects on clinical signs, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, necropsy findings, organ weights, and histopathology in any treatment group. Based on these results, it was concluded that the 3-week repeated oral administration of CS682 to rats did not cause any adverse effects in rats at dose levels of ≤1,000 mg/kg/day. Under these experimental conditions, the NOAEL of CS682 was considered to be over 1,000 mg/kg/day for both sexes.
목차
Materials and Methods
Results
Discussion
Acknowledgments
References
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Addison, J.B / 1984 / Antibiotics in sediments and run-off waters from feedlots / Residue Rev 92 : 1 ~ 24
2. [인터넷자원] - / / AHI (Animal Health Institute)
3. [학술지(정기간행물)] - Bartlett, M.S / 1937 / Properties of sufficiency and statistical test / Proc. R. Soc. London A 160 : 268 ~ 282
4. [단행본] - Boorman, G.A. / 1990 / Pathology of the Fischer Rat. Reference and Atlas / Academic Press
5. [학술지(정기간행물)] - Burn, C.C. / 2006 / Longterm effects of cage-cleaning frequency and bedding type on laboratory rat health, welfare, and handleability: a crosslaboratory study / Lab. Anim 40 : 353 ~ 370
2. [인터넷자원] - / / AHI (Animal Health Institute)
3. [학술지(정기간행물)] - Bartlett, M.S / 1937 / Properties of sufficiency and statistical test / Proc. R. Soc. London A 160 : 268 ~ 282
4. [단행본] - Boorman, G.A. / 1990 / Pathology of the Fischer Rat. Reference and Atlas / Academic Press
5. [학술지(정기간행물)] - Burn, C.C. / 2006 / Longterm effects of cage-cleaning frequency and bedding type on laboratory rat health, welfare, and handleability: a crosslaboratory study / Lab. Anim 40 : 353 ~ 370
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UCI(KEPA) : I410-ECN-0101-2009-510-019510674