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자료유형
학술저널
저자정보
저널정보
한국실험동물학회 Laboratory Animal Research THE KOREAN JOURNAL OF LABORATORY ANIMAL SCIENCE Vol.20 No.3
발행연도
2004.9
수록면
260 - 266 (7page)

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Potassium bromate (KBrO₃), used as a food additive in bakery, has been found to cause problems due to its strong pro-oxidant property. It has been reported that Panax ginseng possesses protective effects against a variety of oxidative damage induced by chemicals such as carbon tetrachloride, acetaminophen, chrome or hyperoxia. Therefore, this study was carried out to investigate the effect of Korean red ginseng saponin (RGS) against oxidative damage induced by KBrO₃ based on the parameters in blood, tissues and urine. Male Sprague-Dawley rats were orally administered with RGS (75 ㎎/㎏) for 2 days, challenged intraperitoneally with KBrO₃ (300 ㎎/㎏) 2 hr after the final administration of RGS, and 48 hr later, blood, kidney and liver tissues, and urine were collected. In hematological analysis, KBrO₃ remarkably increased white blood cells, which was somewhat reduced by treatment with RGS. In blood biochemistry, KBrO₃ markedly increased serum creatinine, blood urea nitrogen, aspartate aminotransferase and alkaline phosphatase, while it decreased uric acid and Ca?? levels, indicative of renal and hepatic toxicities. Such changes were greatly attenuated by RGS treatment. Also, RGS recovered KBrO₃-induced decrease in K? level, although it did not affect the changes in Cl? and osmolarity. In addition, the increases in malondialdehyde contents in kidneys and liver caused by KBrO₃ were fully reversed by RGS. Furthermore, urinary excretion profiles of malondialdehyde and its adducts were affected by RGS treatment; i.e., whereas an increase in excretion of N-ε-(2-propenal)lysine following KBrO₃ challenge was markedly lowered, N-α-acetyl-ε-(2-propenal)lysine and free malondialdehyde were greatly increased by RGS administration. Summarizing the above results, it is suggested that RGS exert protective effect against the renal and hepatic toxicities of KBrO₃ by not only reducing oxidative radical reactions, but also enhancing renal excretion of toxic by-products.

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