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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2001.12
- 수록면
- 211 - 216 (6page)
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This study was carried out to evaluate KBrO₃-induced acute toxicity by clinical pathological parameters in rats. Fourty rats were divided into 4 groups including normal group and three KBrO₃-treated groups with doses of 200, 300, and 400 ㎎/㎏, p.o., respectively. Creatinine and BUN were increased remarkably by KBrO₃ at 400 ㎎/㎏, respectively (p＜0.05, p＜0.01). Phosphorus content increased two times the control at 400 ㎎/㎏ (p＜0.05). Osmolarity was increased, whereas CO₂ content showed decrease at 400 ㎎/㎏, respectively (p＜0.01, p＜0.05). Histopathological findings also showed dose-dependent renal failure. On the other hand, AST was increased three times the control at 400 ㎎/㎏ (p＜0.01). WBC was increased by KBrO₃ depending on the dosage. Platelet was decreased at 200 ㎎/㎏, whereas it was increased at 400 ㎎/㎏ (p＜0.05). The results above suggest that clinical pathological parameters could be used as indices for the evaluation of KBrO₃-induced acute toxic reponse occuring in not only kidney but other organs including liver, when the dosage is as high as 400 ㎎/㎏.
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