지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.12
- 수록면
- 289 - 299 (11page)
이용수
초록· 키워드
오류제보하기
Lipopolysaccharide (LPS) endotoxin is an active component in the outer membrance of Gram-nega-tive bacteria. LPS is usually used as an inflammatory animal model. During the inflammation, diar-rhea and changes in plasma proteins, in hepatic and/or intestinal microsomal cytochrome P450 (CYP) isozymes, and in the renal and/or biliary excretion of drugs have been reported. Thus, in rats pretreated with lipopolysaccharide endotoxin isolated from Klebsiella pneumoniae (KPLPS rats), the absorption, distribution, metabolism, and excretion of drugs could be expected to be altered. Inter-estingly time-dependent effects on the hepatic CYP isozymes have been reported in KPLPS rats. Thus, in KPLPS rats, the pharmacokinetics of drugs which are mainly metabolized via CYP isozymes could be expected to be time-depemdent. In this review, an attempt to explain changes in pharmacokinetics of drug reported in the literacture was made in terms of CYP isozyme changes or urimary and/or biliary excretion changes in KPLPS rats.
목차
INTRODUCTION
DRUGS
CONCLUSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Endotoxin Derived from Escherichia coli Lipopolysaccharide on the Pharmacokinetics of Drugs
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Effects of Water Deprivation on Drug Pharmacokinetics: Correlation between Drug Metabolism and Hepatic CYP Isozymes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
Pharmacokinetic Changes in Drugs during Protein-Calorie Malnutrition： Correlation between Drug Metabolism and Hepatic Microsomal Cytochrome P450 Isozymes
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Effects of Korean traditional herbal formula for common cold on the activities of human CYP450 isozymes
대한한의학회지
2014 .06
-
Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
Toxicological Research
2011 .03
-
Xylene에 의한 CYP2B1/2의 유도와 대사에 있어서 toluene의 영향
한국산업보건학회지
2009 .01
-
열다한소탕과 청심연자탕의 Cytochrome P450 활성 연구
사상체질의학회지
2012 .01
-
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
대한한방내과학회지
2013 .01
-
Prostaglandins Inhibit Cytochrome P450 4A Activity and Contribute to Endotoxin-Induced Hypotension in Rats via Nitric Oxide Production
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2008 .01
-
암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
약학회지
2013 .01
-
Variability in Drug Interaction According to Genetic Polymorphisms in Drug Metabolizing Enzymes
한국환경성돌연변이·발암원학회지
2003 .12
-
Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
Molecular & cellular toxicology
2007 .01
-
Sub-acute toxicity and effect of Hwangryunhaedok-tang on human drug-metabolizing enzymes
대한한의학회지
2017 .06
-
Variability in Drug Interaction According to Genetic Polymorph isms in Drug Metabolizing Enzymes
한국환경성돌연변이·발암원학회지
2004 .03
-
CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E13 Allele Frequencies in Iranian Populations
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Complete Nucleotide Sequence of Cytochrome P450 2E1 Expressed in the Rat Brain
대한의생명과학회지
2005 .06
-
Simultaneous determination of seven major human cytochrome P450 activities using LC/MS/MS
대한약학회 학술대회
2002 .01
-
Purification and Characterization of the Rat Liver CYP2D1 and Utilization of Reconstituted CYP2D1 IN Caffeine Metabolism
한국독성학회지
1997 .03
-
CYP2E1과 CYP2C19 유전자 다형성이 위암 발생 감수성에 미치는 영향
Annals of Surgical Treatment and Research
2007 .08
-
Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-016243779