지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives : The purpose of this study is to investigate the inhibitory or inductive potentials of Yuldahanso-tang (YDT) and Chungsimyonja-tang (CST), herbal formulas for Taeeumin, on cytochrome P450 (CYP450) drug metabolizing enzyme. The mechanisms for the herbal formula-drug interaction has not been well reported in spite of the chance for co-administration with conventional drugs. Methods : To evaluate the interaction potential of YDT-drug or CST-drug, the fluorescence-based enzyme assays on CYP450 isozymes including CYP3A4, CYP2C19, CYP2D6 and CYP2E1 were established in vitro. The inhibitory effects of herbal formulas were characterized with $IC_{50}$ values. Results : YDT showed inhibitory effects on CYP2D6 and CYP2E1-mediated metabolism, while it exhibited week inhibition on CYP3A4 and CYP2C19 relatively. CST exerted relatively weak inhibitory effects on the four CYP450 isozymes compared to that of YDT. Conclusions : These results suggest that the herbal formula-drug interaction could be occur when YDT are co-administered with drugs mediated by CYP2D6 or CYP2E1.
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참고문헌 (24)
참고문헌 신청
Parola M / 2001 / Oxidative stress-related molecules and liver fibrosis / J Hepatol 35:297~306
박영철 / 2011 / 독성학적 측면에서의 한약에 의한 간독성 유발과 기전 / 대한한의학회지 32(4):48~67
Henderson GL / 1999 / Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity / Life Sci 65:PL209~PL214
Paolini M / 1998 / Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases / Life Sci 62:571~582
Tang JC / 2006 / Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity / Phytother Res 20:1046~1051
박영철 / 2011 / 독성학적 측면에서의 한약에 의한 간독성 유발과 기전 / 대한한의학회지 32(4):48~67
Henderson GL / 1999 / Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity / Life Sci 65:PL209~PL214
Paolini M / 1998 / Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases / Life Sci 62:571~582
Tang JC / 2006 / Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity / Phytother Res 20:1046~1051
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