지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Amino acids of histone tail are covalently modified in eukaryotic cells. Lysine residues in histone H3 and H4 are methylated at three levels; mono-, dior trimethylation. Methylation in histones is related with transcription of the genes in distinct pattern depending on lysine residues and methylated levels. Relation between transcription and methylation has been relatively well understood at three lysines H3K4, H3K9 and H3K36. H3K4 is methylated in active or potentially active chromatin and its methylation associates with active transcription. H3K9 is generally methylated in heterochromatin or repressed gene, but trimethylation of this lysine occur in actively transcribed genes also. Methylation at H3K36 generally correlates with active chromatin/transcription, but the correlation of its dimethylation with transcription is controversial. All together methylation patterns of individual lysine residues in histone relate with activation or repression of transcription and may provide distinctive roles in transcriptional regulation of the eukaryotic genes.
목차
서론
H3K4 메틸화
H3K36 메틸화
H3K9 메틸화
히스톤 메틸화 연구 방향
감사의 글
참고문헌
참고문헌 (37)
참고문헌 신청
Bannister, A. J., R. Schneider, F. A. Myers, A. W. Thorne, C. Crane-Robinson and T. Kouzarides. 2005. Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J. Biol. Chem. 280, 17732-17736.
Bannister, A. J., P. Zegerman, J. F. Partridge, E. A. Miska, J. O. Thomas, R. C. Allshire and T. Kouzarides. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124.
Berger, S. L. 2002. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12, 142-148.
Bernstein, B. E., E. L. Humphrey, R. L. Erlich, R. Schneider, P. Bouman, J. S. Liu, T. Kouzarides and S. L. Schreiber. 2002. Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl. Acad. Sci. U. S. A. 99, 8695-8700.
Briggs, S. D., M. Bryk, B. D. Strahl, W. L. Cheung, J. K. Davie, S. Y. Dent, F. Winston and C. D. Allis. 2001. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 15,
Bannister, A. J., P. Zegerman, J. F. Partridge, E. A. Miska, J. O. Thomas, R. C. Allshire and T. Kouzarides. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410, 120-124.
Berger, S. L. 2002. Histone modifications in transcriptional regulation. Curr. Opin. Genet. Dev. 12, 142-148.
Bernstein, B. E., E. L. Humphrey, R. L. Erlich, R. Schneider, P. Bouman, J. S. Liu, T. Kouzarides and S. L. Schreiber. 2002. Methylation of histone H3 Lys 4 in coding regions of active genes. Proc. Natl. Acad. Sci. U. S. A. 99, 8695-8700.
Briggs, S. D., M. Bryk, B. D. Strahl, W. L. Cheung, J. K. Davie, S. Y. Dent, F. Winston and C. D. Allis. 2001. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev. 15,
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Writing, erasing and reading histone lysine methylations
Experimental and Molecular Medicine
2017 .01
-
히스톤 H3 네 번째 라이신 메틸화와 이 효소들의 생리적 역할
미생물학회지
2019 .12
-
히스톤 H3K27 변형과 유전자 전사
생명과학회지
2011 .04
-
Histone Lysine Methylation
생명과학회지
2007 .03
-
Coordinated change of a ratio of methylated H3-Iysine 4 oracetylated H3 to acetylated H4 and DNA methylation isassociated with tissue-specific gene expression in cloned pig
Experimental and Molecular Medicine
2007 .01
-
Histone lysine demethylases in mammalian embryonic development
Experimental and Molecular Medicine
2017 .01
-
Regulatory patterns of histone modifications to control the DNA methylation status at CpG islands
Interdisciplinary Bio Central
2009 .01
-
Increased lysine N-methylation of a 23-kDa protein during hepatic regeneration
Experimental and Molecular Medicine
2005 .01
-
The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat
Experimental and Molecular Medicine
2004 .01
-
Methylation and demethylation of DNA and histones in chromatin: the most complicated epigenetic marker
Experimental and Molecular Medicine
2017 .01
-
Molecular Cloning, Transcriptome Profiling, and Characterization of Histone Genes in the Dinoflagellate Alexandrium pacificum
Journal of Microbiology and Biotechnology
2018 .01
-
Increased methylation of the cytosolic 20-kD protein is accompanied by liver regeneration in a hepatectomized rat
Experimental and Molecular Medicine
2004 .01
-
Context Dependent Histone Modification during Transcription Elongation
한국미생물학회 학술대회논문집
2013 .05
-
Modulation of gene expression dynamics by co-transcriptional histone methylations
Experimental and Molecular Medicine
2017 .01
-
The Roles of Histone H3-K4 Methylation in Morphogenesis of Candida albicans
한국미생물학회 학술대회논문집
2016 .04
-
Histone H3 Lysine Methylation in Adipogenesis
생명과학회지
2020 .08
-
Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells
Genomics & informatics
2012 .01
-
Alteration of DNA Methylation in Gastric Cancer with Chemotherapy
Journal of Microbiology and Biotechnology
2017 .01
-
Chromatin Dynamics during Transcription
한국미생물학회 학술대회논문집
2010 .05
-
Epigenetic regulation and chromatin remodeling in learning and memory
Experimental and Molecular Medicine
2017 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-470-016629500