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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 7 (7page)
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Post-translational modifications, such as methylation, acetylation and phosphorylation, of histone proteins play important roles in regulating dynamic chromatin structure. Histone demethylation has become one of the most active research areas of epigenetics in the past decade. To date, with the exception of histone H3 lysine 79 methylation, the demethylases for all major lysine methylation sites have been discovered. These enzymes have been shown to be involved in various biological processes, with embryonic development being an exciting emerging area. This review will primarily discuss the involvement of these demethylases in the regulation of mammalian embryonic development, including their roles in embryonic stem cell pluripotency, primordial germ cell (PGC) formation and maternal-to-zygotic transition.
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참고문헌 (25)
참고문헌 신청
Adamo A / 2011 / LSD1regulates the balance between self-renewal and differentiation in human embryonic stem cells / Nat Cell Biol 13 : 652 ~ 659
Bernstein BE / 2006 / A bivalent chromatin structure marks key developmental genes in embryonic stem cells / Cell 125 : 315 ~ 326
Byvoet P / 1972 / The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells / Arch Biochem Biophys 148 : 558 ~ 567
Choi J / 2010 / Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors / Biochem Biophys Res Commun 401 : 327 ~ 332
Consortium EP / 2012 / An integrated encyclopedia of DNA elements in the human genome / Nature 489 : 57 ~ 74
Bernstein BE / 2006 / A bivalent chromatin structure marks key developmental genes in embryonic stem cells / Cell 125 : 315 ~ 326
Byvoet P / 1972 / The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells / Arch Biochem Biophys 148 : 558 ~ 567
Choi J / 2010 / Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors / Biochem Biophys Res Commun 401 : 327 ~ 332
Consortium EP / 2012 / An integrated encyclopedia of DNA elements in the human genome / Nature 489 : 57 ~ 74
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