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자료유형
학술저널
저자정보
저널정보
한국생명과학회 생명과학회지 생명과학회지 제16권 제7호
발행연도
2006.12
수록면
1,080 - 1,086 (7page)

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This study was carried out to determine the inhibitory effects of solvent extracts from seven brown algae on mutagenicity using Ames test and growth of AGS human gastric adenocarcinoma and HT-29 human colon cancer cells. The treatment of acetone with methylene chloride and methanol extracts (1.25 mg/assay) from Sargassum horneri to Ames test system inhibited aflatoxin B1 (AFB<SUB>1</SUB>) induced mutagenicity by 96% and 91%, respectively and showed a higher antimutagenic effect than other various marine sources. Similar inhibitory effects were detected in methanol extracts from S. tortile, S. yezoense, S. hemiphyllum and in acetone with methylene chloride extracts from Carpopeltis affinis, S. fulvellum, Colpomenia sinuosa and S. hemiphyllum. In case of N-methyl-N'-nitro-N-nitrosoguamidine (MNNG) induced mutagenicity, the acetone with methylene chloride and methanol extracts from S. yezoense showed 62% and 50% inhibitory rate, respectively, although the inhibitory effect was not stronger compared to AFB<SUB>1</SUB> induced mutagenicity. These results suggest that brown algae have an inhibitory effect to mutagenic agents and that the inhibition was more effective in mutagenicity induced by AFB<SUB>1</SUB> than by MNNG. Inhibitory effects of acetone with methylene chloride and methanol extracts from S. horneri and S. hemiphyllum on the growth of AGS and HT-29 human cancer cells were increased as dose dependent patterns and the methanol extracts showed a stronger inhibitory effect against these cancer cells. The above results indicate that the consumption of these seaweeds may be recommended as potent functional foods for preventing cancer.

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UCI(KEPA) : I410-ECN-0101-2009-470-017616812