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- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제1호
- 발행연도
- 2007.1
- 수록면
- 1 - 6 (6page)
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Background : The use of troglitazone (a PPARγ ligand) and COX-2 inhibitor have been intensively
studied for inhibition of tumor growth in cancer treatment, but the anti-tumor effect with
a combination of these agents for cancer has not yet been studied. The aim of this study was
to determine if low concentrations of troglitazone with COX-2 inhibitor in combination would
cause significant cytotoxicity in glioma cells. Methods : The effects of co-treatment with troglitazone
and COX-2 inhibitor on cell growth and apoptosis were assessed by use of trypan blue
exclusion and a DNA fragmentation assay. A western blot was used to analyze the apoptotic
signaling for the expression of bcl-2, bax, PARP and p21 proteins. Results : A low dose of
troglitazone (5 μM) and COX-2 inhibitor (5 μM) strongly enhanced the cell growth inhibition
and apoptosis in glioma cells when compared to a low dose of each drug alone. Western blotting
analysis showed a decreased expression of bcl-2 and PARP proteins. In contrast, the
bax protein level was increased. Conclusions : The combination of troglitazone and COX-2
inhibitor in a low dose elicits synergistic cytotoxicity in glioma cells. Our study also demonstrates
that down regulation of bcl-2, fragmentation of PARP protein and increased expression of bax
protein were accompanied by co-treatment with troglitazone and the COX-2 inhibitor.
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참고문헌 (29)
참고문헌 신청
/ / The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease 36 (2000) : 151 ~ 169
/ 1995 / Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs a
/ 1996 / Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology 12 : 335 ~ 363
/ 1996 / Prostaglandin synthase 2 1299 : 125 ~ 140
/ 1997 / Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2 99 : 2254 ~ 2259
/ 1995 / Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs a
/ 1996 / Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology 12 : 335 ~ 363
/ 1996 / Prostaglandin synthase 2 1299 : 125 ~ 140
/ 1997 / Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2 99 : 2254 ~ 2259
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15-Hydroxyprostaglandin Dehydrogenase Is Associated with the Troglitazone-Induced Promotion of Adipocyte Differentiation in Human Bone Marrow Mesenchymal Stem Cells
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