지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 181 - 189 (9page)
이용수
초록· 키워드
오류제보하기
Background: The incidence of bacteremia caused by Gram-negative bacteria has increased recently in febrile neutropenic patients with the increase of antibiotic-resistant Gram-negative bacterial infections. This study aimed to identify the distribution of causative bacteria and the proportion of antibiotic-resistant bacteria in bacteremia diagnosed in febrile neutropenic children.
Materials and Methods: The medical records of febrile neutropenic children diagnosed with bacteremia between 2010 and 2014 were retrospectively reviewed. The causative bacteria and proportion of antibiotic-resistant bacteria were investigated and compared yearly during the study period. The clinical impact of antibiotic-resistant bacterial infections was also determined.
Results: A total of 336 bacteremia episodes were identified. During the entire study period, 181 (53.9%) and 155 (46.1%) episodes were caused by Gram-negative and Gram-positive bacteria, respectively. Viridans streptococci (25.9%), Klebsiella spp. (16.7%), and Escherichia coli (16.4%) were the most frequent causative bacteria. The overall distribution of causative bacteria was not significantly different annually. Antibiotic-resistant bacteria were identified in 85 (25.3%) episodes, and the proportion of antibiotic- resistant bacteria was not significantly different annually. Extended-spectrum β-lactamase-producing E. coli and Klebsiella spp.
were most common among antibiotic-resistant Gram-negative bacteria, and they accounted for 30.6% (n = 34) of the identified E. coli and K. pneumoniae. Methicillin-resistant coagulase-negative staphylococci were most common among antibiotic-resistant Gram-positive bacteria, and it accounted for 88.5% (n = 23) of the identified coagulase-negative staphylococci. Antibiotic-resistant bacterial infections, especially antibiotic-resistant Gram-negative bacterial infections, caused significantly higher mortality due to bacteremia compared with non-antibiotic-resistant bacterial infections (P <0.001).
Conclusion: Recently, Gram-negative bacteria caused more bacteremia cases than Gram-positive bacteria in febrile neutropenic children, and antibiotic-resistant Gram-negative bacterial infections increased. Antibiotic-resistant bacterial infections caused poorer prognosis compared with non-antibiotic-resistant bacterial infections, and therefore, continuous surveillance for changing epidemiology of antibiotic-resistant bacterial infections and their clinical impact is necessary.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Freifeld AG / 2011 / Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america / Clin Infect Dis 52:e56~e93
Blennow O / 2016 / The challenge of antibiotic resistance in haematology patients / Br J Haematol 172:497~511
Funada H / 1998 / Changes in the incidence and etiological patterns of bacteremia associated with acute leukemia over a 25-year period / Intern Med 37:1014~1018
Zinner SH / 1999 / Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria / Clin Infect Dis 29:490~494
고은영 / 2011 / 소아 혈액 종양 환자에서 발생한 균혈증의 조사 / Infection and Chemotherapy 43(2):191~197
Blennow O / 2016 / The challenge of antibiotic resistance in haematology patients / Br J Haematol 172:497~511
Funada H / 1998 / Changes in the incidence and etiological patterns of bacteremia associated with acute leukemia over a 25-year period / Intern Med 37:1014~1018
Zinner SH / 1999 / Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria / Clin Infect Dis 29:490~494
고은영 / 2011 / 소아 혈액 종양 환자에서 발생한 균혈증의 조사 / Infection and Chemotherapy 43(2):191~197
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Antibiotic-Resistant Gram-Negative Bacteremia in Febrile Neutropenic Children
Infection and Chemotherapy
2016 .01
-
Trends in the use of antibiotics among Korean children
Clinical and Experimental Pediatrics
2019 .01
-
소아청소년에서의 항생제 사용량 변화에 따른 그람음성 균주의 항생제 내성률 변화 양상
Pediatric Infection and Vaccine
2021 .08
-
Etiology of Bacteremia in Children With Hemato-Oncologic Diseases From 2013 to 2023: A Single Center Study
Pediatric Infection and Vaccine
2024 .04
-
Antibiotic Sensitivity Patterns in Children with Urinary Tract Infection: Retrospective Study Over 8 Years in a Single Center
Childhood Kidney Diseases
2019 .01
-
Correlation of Aminoglycoside Consumption and Amikacin- or Gentamicin-Resistant Pseudomonas aeruginosa in Long-Term Nationwide Analysis: Is Antibiotic Cycling an Effective Policy for Reducing Antimicrobial Resistance?
Annals of Laboratory Medicine
2018 .01
-
광주지역 공공수역의 미생물 군집 다양성 및 항생제 내성에 관한 연구
한국환경보건학회지
2024 .04
-
Change of Antibiotic Resistance to the Causative Organisms of Pelvic Wound Infection for Recent 5 Years
Urogenital Tract Infection
2015 .01
-
The Antibiotic Resistance Pattern of Gram-Negative Bacteria in Children Younger Than 24 Months with a Urinary Tract Infection: A Retrospective Single-Center Study over 15 Consecutive Years
Childhood Kidney Diseases
2015 .01
-
Increasing Antimicrobial Resistance of Escherichia coli Makes Antimicrobial Stewardship More Important
Journal of Korean Medical Science
2019 .01
-
Antibiotic sensitivity and resistance of bacteria from odontogenic maxillofacial abscesses
대한구강악안면외과학회지
2019 .01
-
The change of antibiotic susceptibility in febrile urinary tract infection in childhood and adolescence during the last decade
Investigative and Clinical Urology
2022 .01
-
Bacterial Species and Antibiotic Sensitivity in Korean Patients Diagnosed with Acute Otitis Media and Otitis Media with Effusion
Journal of Korean Medical Science
2017 .01
-
Management of Antibiotic-Resistant Acute Pyelonephritis
Urogenital Tract Infection
2017 .01
-
Development of Antibiotic Classification for Measuring Antibiotic Usage in Korean Hospitals Using a Modified Delphi Method
Journal of Korean Medical Science
2020 .01
-
하천에서의 Oxytetracycline 내성주에 관한 연구
한국환경보건학회지
2015 .01
-
Prophylactic Antimicrobial Therapy and Antimicrobial Stewardship in Urologic Surgery
Urogenital Tract Infection
2023 .04
-
Antibiotic Susceptibility and Treatment Response in Bacterial Skin Infection
Annals of Dermatology
2018 .01
-
단일 3차 의료기관에 내원한 당뇨병성 족부병변 환자의 창상 배양검사를 통한 세균 검출 현황
대한족부족관절학회지
2021 .01
-
Microbiology and Antimicrobial Therapy for Diabetic Foot Infections
Infection and Chemotherapy
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0