지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Neutrophils are short-lived leukocytes that play a vital role in immune responses to bacteria, yeast, and fungi. This study was performed to investigate the effect of 4-O-methyl-ascochlorin (MAC), an anti-tumor, antibiotic, and anti-fungal prenyl-phenol compound on the spontaneous apoptosis of human neutrophils. MAC time- and dose-dependently accelerated the spontaneous apoptosis of human neutrophils. The effect of MAC on neutrophil apoptosis was blocked by pre-treatment of the neutrophils with specific inhibitors of pancaspase (zVAD-fmk), caspase-8 (zIETD-fmk), or caspase-3 (zDEVD-fmk). The cleavage of procaspase-8 and procaspase-3 was increased by MAC. Mitochondrial permeability, which was measured by the retention of DiOC_6(3), was dose-dependently increased by MAC but the change of mitochondrial permeability was not blocked by pretreatment of neutrophils with zIETD-fmk. These results suggest that MAC induces neutrophil apoptosis by caspase-8-dependent but mitochondria-independent manner.
목차
Abstract
재료 및 방법
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감사의 글
참고문헌
참고문헌 (22)
참고문헌 신청
Akgul, C., D. A. Moulding and S. W. Edwards. 2001. Molecular control of neutrophil apoptosis. FEBS Lett. 487, 318-322.
Fossati, G., D. A. Moulding, D. G. Spiller, R. J. Moots, M. R. White and S. W. Edwards. 2003. The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J. Immunol. 170, 196
Healy, D. A., R. W. Watson and P. Newsholme. 2002, Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils. Clin. Sci. (Lond). 103, 179-189.
Hong, S., K. K. Park, J. Magae, K. Ando, T. S. Lee, T. K. Kwon, J. Y. Kwak, C. H. Kim and Y. C. Chang. 2005. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1- mediated gene expression through the ERK1/2 signali
Hosokawa, T., T. Okutomi, M. Sawada, K. Ando and G. Tamura. 1981. Unusual concentration of urine and prevention of polydipsia by fungal prenylphenols in DOCA hypertensive rats. Eur. J. Pharmacol. 69, 429-438.
Fossati, G., D. A. Moulding, D. G. Spiller, R. J. Moots, M. R. White and S. W. Edwards. 2003. The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J. Immunol. 170, 196
Healy, D. A., R. W. Watson and P. Newsholme. 2002, Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils. Clin. Sci. (Lond). 103, 179-189.
Hong, S., K. K. Park, J. Magae, K. Ando, T. S. Lee, T. K. Kwon, J. Y. Kwak, C. H. Kim and Y. C. Chang. 2005. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1- mediated gene expression through the ERK1/2 signali
Hosokawa, T., T. Okutomi, M. Sawada, K. Ando and G. Tamura. 1981. Unusual concentration of urine and prevention of polydipsia by fungal prenylphenols in DOCA hypertensive rats. Eur. J. Pharmacol. 69, 429-438.
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UCI(KEPA) : I410-ECN-0101-2009-470-015376155