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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 230 - 236 (7page)
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Dermatophagoides pteronissinus (DP) is one of the house dust mites (HDM) associated with allergic diseases. The cysteine protease Der p 1 from DP is a powerful allergen. The pathogenic mechanism of allergy is involved in cytokine secretion of lymphocytes and spontaneous apoptosis of neutrophils. In this study, we investigated whether Der p 1 induces cytokine secretion of lymphocytes and if the release of cytokines is associated with regulation of neutrophil apoptosis. In normal and allergic subjects, Der p 1 increased IL-6, IL-8, MCP-1, and GM-CSF release in a time-dependent course. Supernatants collected from normal and allergic neutrophils after Der p 1 stimulation suppressed the apoptosis of normal and allergic neutrophils, although Der p 1 alone has no effect on neutrophils. Der p 1 suppressed neutrophil apoptosis in coculture of normal neutrophils with normal lymphocytes. Der p 1 more strongly suppressed apoptosis of allergic neutrophils cocultured with allergic lymphocytes than normal neutrophils cocultured with normal lymphocytes. In summary, Der p 1 increases the secretion of cytokines, which has anti-apoptotic effects on neutrophils of normal and allergic subjects. These results will contribute to elucidate the pathogenic mechanism of allergic diseases.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Allen JE / 2015 / IL-17 and neutrophils: unexpected players in the type 2 immune response / Curr Opin Immunol 34 : 99 ~ 106
Gabay C / 2006 / Interleukin-6 and chronic inflammation / Arthritis Res Ther 8 (Suppl 2) : S3 ~
Ghaemmaghami AM / 2001 / Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 condition
Ghaemmaghami AM / 2002 / The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias
Holgate ST / 2008 / Pathogenesis of asthma / Clin Exp Allergy 38 : 872 ~ 897
Gabay C / 2006 / Interleukin-6 and chronic inflammation / Arthritis Res Ther 8 (Suppl 2) : S3 ~
Ghaemmaghami AM / 2001 / Human T cell subset commitment determined by the intrinsic property of antigen: the proteolytic activity of the major mite allergen Der p 1 condition
Ghaemmaghami AM / 2002 / The proteolytic activity of the major dust mite allergen Der p 1 conditions dendritic cells to produce less interleukin-12: allergen-induced Th2 bias
Holgate ST / 2008 / Pathogenesis of asthma / Clin Exp Allergy 38 : 872 ~ 897
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