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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국현미경학회 한국현미경학회지 한국현미경학회지 제38권 제4호
발행연도
2008.1
수록면
293 - 306 (14page)

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The essential factor of acute respiratory distress syndrome (ARDS), an acute lung injury accompanied commonly by sepsis syndrome is accumulation of neutrophils in lung tissue. The study attempted to confirm whether a lung injury would be decreased with the anti-inflammatory effect of germanium by the treated germanium prior to the development of ARDS and whether nitric oxide influence in suppressing a lung injury. Test groups were divided in the following structure for experiment; CON that has been administered with sodium chloride to airway, LPS administered with endotoxin for 5 hours in the same amount and 5 hours of endotoxin administered Ge+LPS following 1 hours of pre-treated germanium. The result of a test using experimental animals, infilteration of neutrophils (p⁄0.001) in bronchoalveolar lavage fluid (BALF) was significantly decreased, the structure of lung tissue was preserved relatively well, and much neutrophils with distinct positive were observed on tunel staining which showed increase of apoptotic neutrophils in the pre-treated germanium group compare to the endotoxin administrated group. In observation of ultrastructural changes of cell in BALF, phagocytic alveolar macrophage was increased in alveolar space, the nucleus of most engulfed neutrophils were condensed, and some apoptosis neutrophils appears to be DNA fragmentation and effacement of cellular organelles were found in intercellular matrix in the pre-treated germanium group. However, the nitric oxide showed increase in all the groups excluding CON, and the nitric oxide effect such as degranulation diminishing of mast cells and apoptosis increase of neutrophils in the pre-treated group only. The situation appears that there was change in internal environment of the experimental animal by the pre-treated germanium before the nitric oxide is produced and the anti-inflammatory effect activated the pre-processed germanium by nitric oxide which activated following the change. Therefore, the nitric oxide created from macrophage in accordance with the pre-treated germanium appears to influence in alleviating a lung injury. Accordingly, acute lung injury is alleviated by the anti-inflammatory effect of germanium such as inhibition of neutrophils migration,induction of neutrophil apoptosis and increase of phagocytic function of phagocyte, and the nitric oxide produced from activated macrophage by germanium would influence in suppressing a lung injury.
#Acute lung injury #Germanium #Neutrophil #Apoptosis

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참고문헌 (24)

참고문헌 신청
Abraham E / 2003 / Neutrophils and acute lung injury / Crit Care Med 31 (4) : S195 ~ S199 google schola Aoki N / 1990 / Beneficial effects of two forms of NO administration in feline splanchnic artery occlusion shock / Am J Physiol 258 (2) : G275 ~ G281 google schola Artman M / 1979 / Nicotinamide adenine dinucleotide-splitting enzyme in normal, elicited and activated peritoneal macrophages of the mouse / J Reticuloendothel Soc 25 (5) : 4 google schola Ashbaugh DG / 1967 / Acute respiratory distress in adults / Lancet 2 (7511) : 319 ~ 323 google schola Aso H / 1985 / Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, an organic germanium compound / Microbiol Immunol google schola

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