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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 102 - 108 (7page)
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Der p 2 is the major allergen of the house dust mite (HDM) associated with the development of allergic diseases. The pathogenic mechanism of the allergy is related to cytokine release of lymphocytes and constitutive apoptosis of neutrophils. In the present study, we examined whether Der p 2 induces cytokine release of lymphocytes, which is involved in regulation of neutrophil apoptosis. In normal and allergic subjects, Der p 2 enhanced the secretion of IL-6, IL-8, MCP-1, and GM-CSF in a time-dependent manner. Although Der p 2 was weakly effective against neutrophil apoptosis, conditioned media collected from normal and allergic lymphocytes after Der p 2 treatment inhibited the apoptosis of normal and allergic neutrophils. Der p 2 showed stronger inhibition of apoptosis of allergic neutrophils cocultured with allergic lymphocytes than normal neutrophils cocultured with normal lymphocytes. These findings improve our understanding of the role of Der p 2 in regulation of lymphocytes and neutrophils and will enable elucidation of allergy pathogenesis.
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참고문헌 (23)
참고문헌 신청
Hogate ST / 2008 / Pathogenesis of asthma / Clin Exp Allergy 38:872~897
Rondón C / 2012 / Local allergic rhinitis : concept, pathophysiology, and management / J Allergy Clin Immunol 129:1460~1467
김인식 / 2014 / Suppressive Effect of Arazyme on Neutrophil Apoptosis in Normal and Allergic Subjects / 대한의생명과학회지 20(4):244~249
김인식 / 2015 / Der p 1 Inhibits Spontaneous Neutrophil Apoptosis by Cytokine Secretion of Normal and Allergic Lymphocytes / 대한임상검사과학회지 47(4):230~236
Gaffin, JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9:128~135
Rondón C / 2012 / Local allergic rhinitis : concept, pathophysiology, and management / J Allergy Clin Immunol 129:1460~1467
김인식 / 2014 / Suppressive Effect of Arazyme on Neutrophil Apoptosis in Normal and Allergic Subjects / 대한의생명과학회지 20(4):244~249
김인식 / 2015 / Der p 1 Inhibits Spontaneous Neutrophil Apoptosis by Cytokine Secretion of Normal and Allergic Lymphocytes / 대한임상검사과학회지 47(4):230~236
Gaffin, JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9:128~135
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