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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.4 No.1
- 발행연도
- 1999.3
- 수록면
- 75 - 78 (4page)
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초록· 키워드
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Acetylcarnitine, a metabolite of carnitine, has been proven to be a potent inhibitor of ethanol oxidation in hepatocytes. It inhibits the activity of alcohol dehydrogenase (ADH), but not the microsomal ethanol oxidizing system, which was significantly inhibited by acetylcarnitine at NAD:acetylcarnitine≤1. The main objectives of this study were to ascertain the interaction between acetylcarnitine and NAD on ADH activity and to elucidate whether different species have different effects. The post-microsomal supernatant (PMS) was prepared from normal rat, guinea pig, mouse and broilers by differential centrifugation. Horse and yeast ADH were purchased from the Sigma Chemical Co. Prepared and purchased ADH are used for determination of ADH activity in the presence or absence of carnitine and acetylcarnitine. Binding studies showed that acetylcarnitine did bind to ADH in a dose related manner when low NAD:acetylcarnitine ratio was provided. It was found that the inhibition of ADH activity occurred only when NAD concentration was less than the inhibitor concentration. Crystalline and crude ADH preparations from different vertebrate species were inhibited by acetylcarnitine, whereas the yeast ADH was not affected by acetylcarnitine.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
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