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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.3 No.4
- 발행연도
- 1998.12
- 수록면
- 351 - 355 (5page)
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The purpose of this study was to investigate the effect of protein and dietary fiber levels on the activities of ethanol metabolizing enzymes of the brain in acute and chronic ethanol-treated rats. Male Sprague-Dawley rats were fed on diets containing two levels of protein (7%, 20%) with two levels of fiber (5%, 10%) for 5 weeks. Rats were orally administered 40% (v/v) ethanol (5 g/㎏ body weight) 90 min before decapitation in the acute ethanol-treated groups and 25% (v/v) ethanol (5 g/㎏ body weight) once a day for 5 weeks in the chronic ethanol-treated groups. Cytosolic alcohol dehydrogenase (ADH) activities were higher than those of mitochondrial ADH. The ADH activities were increased by 20% protein and 5 % fiber levels in the diet in two fractions, but were decreased by chronic ethanol treatment. Mitochondrial aldehyde dehydrogenase (ALDH) activities did not change by ethanol treatment but were increased by the 20% protein level. However, cytosolic ALDH activities were decreased by chronic ethanol treatment at the 5% fiber level and did not change with protein levels. Both ALDH activities were higher in the 10% fiber groups than the 5% fiber groups. Cytochrome P-450 contents were significantly increased in the chronic ethanol-treated groups but xanthine oxidase (XO) activities did not change. P-450 contents and XO activities were significantly decreased in both the low protein and fiber groups.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-511-018074783