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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.9
- 수록면
- 215 - 221 (7page)
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초록· 키워드
오류제보하기
Environmental polycyclic aromatic hydrocarbones (PAHs), which are formed during incomplete combustion of fossil fuels, are widely distributed in our environment. Human exposure to PAHs may occur through smoking, polluted air, food consumption and occupational contact. Urinary naphthols, 1-and 2-naphthol, have been suggested as route-specific biomarkers for exposure to airborne PAHs. Cytochrome p450 2E1 (CYP2E1) is known to be a great importance for the metabolism of organic solvents, which is a precacinogens with small molecular weight. This study describes the metabolic differences between PstI and RsaI polymorphisms (c1 allele: PstI-, RsaI±; c2 allele: PstI±, RsaI-) of CYP2E1 5-flanking region by genetically modified HepG2 cells, which overexpress the polymorphic regions. The results of CAT assay and western blot in the c2 allele overexpressed cells have higher activities than the c1 allele over-expressing cells. However, the metabolism of naphthalene to 2-naphthol has no difference due to the two genotypes. In this study, we established the CYP2E1 polymorphic allele transduced HepG2 cells to screen susceptibility-differences in PAH exposure. In conclusion, the CYP2E1 polymorphism may hardly induce susceptibility differences in PAH exposure monitoring with urinary naphthols.
목차
ABSTRACT
서론
재료 및 방법
결과
고찰
결론
감사의 글
참고문헌
참고문헌 (16)
참고문헌 신청
[학술지(정기간행물)] - / 2000 / Expression ofhGSTP1 alleles in human lung and catalytic activity ofthe native protein variants towards 1-chloro-2 156 (2) : 167 ~ 175
[학술지(정기간행물)] - / 1997 / Genetic polymorphism of human CYP2E1 characterization of two variant alleles 51 (3) : 370 ~ 376
[학술지(정기간행물)] - / 1999 / Structural and functional characterization of the 5′-flanking region of the rat and human cytochrome P4502E1 genes identification of a polymorphic repeat in thehuman gene 263 : 286 ~ 293
[학술지(정기간행물)] - / 1995 / Effects of ALDH2 and CYP-2E1 geneticpolymorphisms and smoking and drinking habits ontoluene metabolism in humans 113 (2) : 295 ~ 304
[학술지(정기간행물)] - / 1999 / Genetic polymorphisms inmetabolic enzymes and metabolism of carcinogens Search for black boxes of environment-induced cancers Challenge of molecular epidemiologyin occupational medicine Institute of OccupationalScience Press : 137 ~ 152
[학술지(정기간행물)] - / 1997 / Genetic polymorphism of human CYP2E1 characterization of two variant alleles 51 (3) : 370 ~ 376
[학술지(정기간행물)] - / 1999 / Structural and functional characterization of the 5′-flanking region of the rat and human cytochrome P4502E1 genes identification of a polymorphic repeat in thehuman gene 263 : 286 ~ 293
[학술지(정기간행물)] - / 1995 / Effects of ALDH2 and CYP-2E1 geneticpolymorphisms and smoking and drinking habits ontoluene metabolism in humans 113 (2) : 295 ~ 304
[학술지(정기간행물)] - / 1999 / Genetic polymorphisms inmetabolic enzymes and metabolism of carcinogens Search for black boxes of environment-induced cancers Challenge of molecular epidemiologyin occupational medicine Institute of OccupationalScience Press : 137 ~ 152
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CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E13 Allele Frequencies in Iranian Populations
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Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
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벤젠 대사에 있어서 CYP2E1 유전자다형성의 영향
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Preferential Induction of CYP1A1 over CYP1B1 in Human Breast Cancer MCF-7 Cells after Exposure to Berberine
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Relationship between the Polymorphism of Cytochrome P-450 2D6 and Theclinical Outcomes of Paroxetine in Korean Patients with Depressive Disorders
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Relationship between CYP17 and CYP11${\alpha}$, and PCOS in Korean Population
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Bioassays of Polycyclic Aromatic Hydrocarbons using CYP1A1-luciferase Reporter Gene Expression System in Human Breast Cancer MCF-7 Cells
한국환경성돌연변이·발암원학회지
2003 .06
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암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
약학회지
2013 .01
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Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone
Journal of Pharmaceutical Investigation
2020 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
직업과 생활 습관, 그리고 CYP1A1, GSTM1, GSTT1 유전자 다형성이 요중 1-hydroxypyrene과 2-naphthol 농도에 미치는 영향
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UCI(KEPA) : I410-ECN-0101-2009-539-018068327