지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.3
- 수록면
- 19 - 24 (6page)
이용수
초록· 키워드
오류제보하기
In order to understand the mechanism of the regulation of drug metabolizing enzyme gene expression, we have studied the induction of CYP1A1 and GSTα, μ, π enzymes in Japanese monkey and rhesus monkey after the treatment with 3-methylcholanthrene (3MC) and di-n-butyl phthalate (DBP) and bisphenol A (BPA), The levels of mRNA were measured by RT-PCR in brain, intestine and liver. In the case of adult monkey, treatment with 3MC induced CYP1A1 mRNA in intestine by 11-fold. The treatment with DBP induced CYP1A1 mRNA. Effects of 3MC and DBP on GST mRNA expression was not clear. But GSTμ was slightly inhibited by the treatment with 3MC and DBP. GSTα was induced in intestine by 1.5-fold. GSTπ was slightly induced by the treatment with 3MC and DBP in intestine. In the case of fetus monkey, the basal levels of fetus CYP1A1 mRNA and GSTs mRNA were relatively low compared to adult monkey. As the age of monkey increased, the basal levels of CYP1A1 mRNA were also increased. 3MC induced the expression of CYP1A1 mRNA didn't significantly induce CYP1A1 mRNA in intestine. The levels of GSTμ and GSTπ were not changed by the treatment with 3MC and DBP. GSTπ was slightly induced by the treatment with 3MC and DBP.
목차
ABSTRACT
서론
실험 재료 및 방법
결과
고찰
감사의 글
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
원숭이 뇌 약물대사효소 유전자 발현에 미치는 3-methylcholanthrene 영향
한국환경성돌연변이·발암원학회지
2004 .03
-
원숭이 간 약물대사효소 유전자 발현에 미치는 3-methylcholanthrene 영향
한국환경성돌연변이·발암원학회지
2004 .06
-
The potent protective effect of red ginseng against acetaminophen-induced toxicity through metabolic regulation of CYP2E1 and GSTs
고려인삼학회 학술대회
2008 .12
-
Lack of Association between Glutathione S-Transferase-M1, -T1, and -P1 Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients
PSYCHIATRY INVESTIGATION
2010 .01
-
Preferential Induction of CYP1A1 over CYP1B1 in Human Breast Cancer MCF-7 Cells after Exposure to Berberine
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Effects of CYP1A2$^*$1C and CYP1A2$^*$1F Genotypes on the Activity and Inducibility of CYP1A2 Determined by Urinary Caffeine Metabolite Ratio in Koreans
Molecular & cellular toxicology
2007 .01
-
Expression of CYP2A6, CYP2D6 and CYP4A11 Polymorphisms in COS7 Mammalian Cell Line
Toxicological Research
2011 .03
-
DNCB로 유발된 생쥐의 알레르기접촉피부염에 갈근승기탕(葛根承氣湯)이 미치는 영향
JSCM : Journal of Sasang constitutional medicine
2015 .01
-
Effects of Korean traditional herbal formula for common cold on the activities of human CYP450 isozymes
대한한의학회지
2014 .06
-
RNA Expression of Cytochrome P450 in Mexican Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
CYP2E15B, CYP2E16, CYP2E17B, CYP2E12, and CYP2E13 Allele Frequencies in Iranian Populations
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
약물대사효소 CYP2C19, CYP2D6의 다형성과 사상체질의 관련성 연구
대한한의학회지
2007 .03
-
CYP2E1과 CYP2C19 유전자 다형성이 위암 발생 감수성에 미치는 영향
Annals of Surgical Treatment and Research
2007 .08
-
한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
대한한방내과학회지
2013 .01
-
Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
가미사물탕(GST)의 사이토카인으로 유도된 인간 섬유아세포양 활막 세포 활성화 저해 작용
논문집 : 대전대학교 한의학연구소. 한의학편
2005 .01
-
한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
생물정신의학
2000 .01
-
암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
약학회지
2013 .01
-
Diethylnitrosamine에 의하여 유발된 마우스 간 종양의 CYP1A2 메틸화와 발현
한국환경성돌연변이·발암원학회지
2006 .09
-
Nonylphenol이 CYP17 및 CYP19발현에 미치는 영향
Environmental Analysis Health and Toxicology
2005 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-476-017705452