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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.9
- 수록면
- 31 - 41 (11page)
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This work aimed to study the effectiveness of cellular oxidative parameter (malondialdehyde,
protein carbonyl, and 8-hydroxy-2'deoxyguanosine). The experimental groups were aluminum
treated rats and control rats. Aluminum treatd rats were given intraperitoneally aluminum nitrate
nonahydrate (Al3+, 0.2 mmol/kg) daily for 30 days except Sunday. Control rats were injected 1 ml of
saline. After the dose, rats were decapitated and hippocampus and cerebral cortex were removed.
The measured parameters were tissue malondialdehyde (MDA, index of lipid peroxidation), protein
carbonyl (index of protein oxidation), 8-hydroxy-2'-deoxy-guanosine (8-OHdG, index of DNA oxidation),
reduced glutathione (GSH) levels as well as glutathione reductase (GR) and catalase. Al concentrations
in the tissues were also measured. All results were corrected by tissue protein levels. The
results were as followed; 1. The concentrations of Al in the cortex and hippocampus were significantly
higher in the Al-treated rats than in the control rats. 2. Antioxidative enzyme's activity, catalase
and GR, were significantly higher in the Al-treated rats than the control rats. GSH levels were also
higher in the Al-treated rats. 3. MDA, protein carbonyl, and 8-OHdG concentration of Al-treated rats
were significantly higher than those of control rats. 4. The concentrations of antioxidants, and oxidative
stress parameter were correlated with the concentrations of Al in hippocampus and cerebral cortex.
Catalase and GR activity were also correlated with the concentration of Al. Based on these
results, it can be suggested that intraperitoneally injected Al was accumulated in the brain and
induced the increase of antioxidant levels and antioxidatve enzyme activity. Also, the oxidative products
of cellular macromolecules are significantly related to tissue Al concentration. Therefore MDA,
protein carbonyl, and 8-OHdG are useful markers for oxidative stress on cellular macromolecules.
protein carbonyl, and 8-hydroxy-2'deoxyguanosine). The experimental groups were aluminum
treated rats and control rats. Aluminum treatd rats were given intraperitoneally aluminum nitrate
nonahydrate (Al3+, 0.2 mmol/kg) daily for 30 days except Sunday. Control rats were injected 1 ml of
saline. After the dose, rats were decapitated and hippocampus and cerebral cortex were removed.
The measured parameters were tissue malondialdehyde (MDA, index of lipid peroxidation), protein
carbonyl (index of protein oxidation), 8-hydroxy-2'-deoxy-guanosine (8-OHdG, index of DNA oxidation),
reduced glutathione (GSH) levels as well as glutathione reductase (GR) and catalase. Al concentrations
in the tissues were also measured. All results were corrected by tissue protein levels. The
results were as followed; 1. The concentrations of Al in the cortex and hippocampus were significantly
higher in the Al-treated rats than in the control rats. 2. Antioxidative enzyme's activity, catalase
and GR, were significantly higher in the Al-treated rats than the control rats. GSH levels were also
higher in the Al-treated rats. 3. MDA, protein carbonyl, and 8-OHdG concentration of Al-treated rats
were significantly higher than those of control rats. 4. The concentrations of antioxidants, and oxidative
stress parameter were correlated with the concentrations of Al in hippocampus and cerebral cortex.
Catalase and GR activity were also correlated with the concentration of Al. Based on these
results, it can be suggested that intraperitoneally injected Al was accumulated in the brain and
induced the increase of antioxidant levels and antioxidatve enzyme activity. Also, the oxidative products
of cellular macromolecules are significantly related to tissue Al concentration. Therefore MDA,
protein carbonyl, and 8-OHdG are useful markers for oxidative stress on cellular macromolecules.
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