지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2010.2
- 수록면
- 84 - 88 (5page)
이용수
초록· 키워드
오류제보하기
Rats have been widely used as an animal model in biomedical research. At present, to produce knockout rats, N-ethyl-N-nitrosourea (ENU) mutagenesis followed by screening for mutations within the targeted gene seems to be the most promising. We have recently produced a rat mutant archive consisting of cryopreserved sperms derived from ~5,000 ENU-mutagenized male rats and corresponding DNA samples (Mashimo et al, Nat Genet, 2008). The mutant archive is estimated to store ~2 million mutations, sufficient to identify several mutations in a particular gene of interest. From the archive, different gene-targeted rats were successfully isolated and established as disease models.
For example, we have recently established a novel Apc-mutant rat strain, Kyoto Apc Delta (KAD), which carried a nonsense mutation in rat Apc exon 15. The KAD rat showed no spontaneous tumor in the gut, but showed increased susceptibility to colitis-associated colon carcinogenesis induced by azoxymethane and dextran sodium sulfate, compared with the control F344 rat (Yoshimi et al, Cancer Sci, 2009). The usefulness of the KAD rat in investigating colon carcinogenesis and developing effective prevention, diagnosis, and treatment of colon cancer will be discussed.
For example, we have recently established a novel Apc-mutant rat strain, Kyoto Apc Delta (KAD), which carried a nonsense mutation in rat Apc exon 15. The KAD rat showed no spontaneous tumor in the gut, but showed increased susceptibility to colitis-associated colon carcinogenesis induced by azoxymethane and dextran sodium sulfate, compared with the control F344 rat (Yoshimi et al, Cancer Sci, 2009). The usefulness of the KAD rat in investigating colon carcinogenesis and developing effective prevention, diagnosis, and treatment of colon cancer will be discussed.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
한국인 대장암 환자의 종양조직에서 APC 유전자변이
Annals of Surgical Treatment and Research
2009 .03
-
Modifying Effect of Indole-3-carbinol on the Rat Colon Carcinogenesis
Laboratory Animal Research
2010 .12
-
BASIC PROCEDURES IN THE RAT
대한외과학회 학술대회 초록집
1998 .11
-
Effect of Aging on the Xylene Metabolism in CCl₄-Induced Liver Damaged Rats
대한의생명과학회지
2001 .09
-
Chemopreventive effects of 2-(allylthio)pyrazine on rat colon carcinogenesis induced by azoxymethane
한국보건교육건강증진학회 학술대회 발표논문집
1998 .11
-
Evaluation of DEN-induced Carcinogenesis in Wistar Rats
한국실험동물학회 학술발표대회 논문집
2007 .06
-
N-ethyl-N-nitrosourea mutagenesis : 질환모델동물의 개발
Laboratory Animal Research
2004 .06
-
방사선조사가 저칼슘식이 백서 치주조직에 미치는 영향에 관한 연구
치과방사선
1992 .01
-
Effects of Nonylphenol on the Experimental Liver Carcinogenesis in Male F344 Rats
한국실험동물학회 학술발표대회 논문집
2004 .06
-
MR imaging of Rat balloon injury models of endovascular lesions in rat arteries
한국실험동물학회 학술발표대회 논문집
2012 .08
-
가축과 실험동물의 생리자료(12)-6 -제12장 쥐(The Rat)-6 -제12장 쥐(The Rat)-6
대한생리학회지
1984 .01
-
The National Bio Resource Project for the Rat in Japan : Systematic Accumulation, Storage and Provision of Valuable Rat Strains
한국실험동물학회 학술발표대회 논문집
2005 .06
-
합곡(合谷) 침자극(鍼刺戟)이 동통억제(疼痛抑制)에 미치는 영향(影響)
대한침구의학회지
1998 .01
-
노화초기 백서 신장에서의 Nitric Oxide Synthase 발현
Journal of Pathology and Translational Medicine
2004 .01
-
Colon Cancer Prevention by Detection of APC Gene Mutation in a Family with Attenuated Familial Adenomatous Polyposis
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Rat에서 실험적 출혈성 쇽 모델
대한외과학회 학술대회 초록집
1992 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2010-510-002595246