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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 374 - 378 (5page)
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The purpose of the present study was to investigate the effects of resveratrol supplementation on oxidative damage and lipid peroxidation induced by strenuous exercise in rats. The rats were randomly divided into five groups: a sedentary control group, an exercise control group, and three treatment exercise groups administered increasing doses of resveratrol (25, 50, and 100 mg/kg body weight). Resveratrol was administered by oral gavage once daily for four weeks. At the end of the four-week period, the rats performed a strenuous exercise on the treadmill, and the levels of lactate dehydrogenase (LDH), creatine kinase (CK), malondialdehyde (MDA), 4-hydroxy-2-nonenal (4-HNE), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured. The results showed that resveratrol supplementation had protective effects against strenuous exercise-induced oxidative damage and lipid peroxidation by lowering the levels of LDH, CK, MDA, 4-HNE, and 8-OHdG in the serum or muscle of rats. These beneficial effects are probably owing to the inherent antioxidant activities of resveratrol.
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참고문헌 (25)
참고문헌 신청
Aguiló, A. / 2005 / Antioxidant response to oxidative stress induced by exhaustive exercise / Physiol. Behav 84:1~7
Belviranl, M. / 2012 / Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats / Br. J. Nutr 108:249~256
Browning, J. D. / 2004 / Molecular mediators of hepatic steatosis and liver injury / J. Clin. Invest 114:147~152
Ceci, R. / 2015 / Effects of tadalafi l administration on plasma markers of exercise-induced muscle damage, IL6and antioxidant status capacity / Eur. J. Appl. Physiol 115:531~539
Gehm, B. D. / 1997 / Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor / Proc. Natl. Acad. Sci. U.S. A 94:14138~14143
Belviranl, M. / 2012 / Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats / Br. J. Nutr 108:249~256
Browning, J. D. / 2004 / Molecular mediators of hepatic steatosis and liver injury / J. Clin. Invest 114:147~152
Ceci, R. / 2015 / Effects of tadalafi l administration on plasma markers of exercise-induced muscle damage, IL6and antioxidant status capacity / Eur. J. Appl. Physiol 115:531~539
Gehm, B. D. / 1997 / Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor / Proc. Natl. Acad. Sci. U.S. A 94:14138~14143
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