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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 638 - 645 (8page)
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초록· 키워드
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Objectives: For the risk management of airborne fungal diseases, our aim was to evaluate airborne fungi and study the toxicity associated with fungal allergic diseases using fungal species native to Korea. Methods: Fungi were isolated from outdoor air samples collected from Seoul, Incheon, Cheonan, Gwangju, Ulsan, Busan, and Jeju and tested for their cytotoxicity potential and their ability to induce proliferation and secretion of macrophage-derived chemokine (MDC) in human mast cells (HMC-1). Results: More than 18 species of fungi were collected from outdoor air in Korea over one year, and the strains were identified and systematically analyzed. The results showed that the Cladosporium (59%) and Alternaria (22%) strains are the most common in outdoor air. Three of the collected strains (Fusarium, Trichoderma, and Penicillium) showed mild toxicity in cells involved in allergic inflammation, and twelve induced cell proliferation in HMC-1 cells. More importantly, many strains (Edgeworthia, Trametes, Emmia, Irpex, Talaromyces, Penicillium, Periconia, Epicocum, Bipolaris) induced the MDC protein in activated HMC-1 cells. Conclusion: Nineteen percent of the tested strains caused cytotoxicity in mast cell lines, whereas, most of the non-toxic strains contributed to cell activity. Among the tested strains, more than 80% increased the expression of MDC protein, which contributes to the severity of atopic dermatitis, asthma, and rhinitis. It is, in fact, one of the markers for these conditions. Therefore, airborne fungus could be considered as an important marker for environmental risk management for allergic diseases in Korea.
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참고문헌 (19)
참고문헌 신청
Kim CH / 2001 / Distribution of fungus spores in the air of outdoor and indoor environment from September to November 1999 in Seoul / Korea J Asthma Allergy Clin Immunol 21:970~976
방종일 / 2018 / 외기 중 미세먼지의 공동주택 실내 유입에 관한 연구 / 대한건축학회논문집 구조계 38(1):61~68
Park HJ / 1995 / A survey of airborne fungal spores in Seoul, Korea / Korean J Asthma Allergy Clin Immunol 15:216~222
Lee PH / 2016 / Analysis of Medical Trends of ‘Environmental Diseases’ in the Recent 5 Years / HIRA Policy Trends 10(1):59~65
송주희 / 2007 / 서울시 일부 종합병원의 공기 중 미생물 농도 분포 / 한국환경보건학회지 33(2):104~114
방종일 / 2018 / 외기 중 미세먼지의 공동주택 실내 유입에 관한 연구 / 대한건축학회논문집 구조계 38(1):61~68
Park HJ / 1995 / A survey of airborne fungal spores in Seoul, Korea / Korean J Asthma Allergy Clin Immunol 15:216~222
Lee PH / 2016 / Analysis of Medical Trends of ‘Environmental Diseases’ in the Recent 5 Years / HIRA Policy Trends 10(1):59~65
송주희 / 2007 / 서울시 일부 종합병원의 공기 중 미생물 농도 분포 / 한국환경보건학회지 33(2):104~114
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