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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 186 - 191 (6page)
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High-grade transformation of low-grade gliomas has long been a poor prognostic factor during thera- py. In 2016, the World Health Organization (WHO) Classification of Tumors of the Central Nervous Sys- tem (CNS) adopted isocitrate dehydrogenase (IDH) mutation status in the classification of diffuse astro- cytomas. The 2021 classification denoted glioblastomas as IDH-wildtype and graded IDH-mutant astrocytomas as 2, 3, or 4. Gemistocytic morphology, a large proportion of residual tumor, the patient’s age, and recurrence after radiotherapy were previously mentioned as risk factors for high-grade trans- formation of low-grade gliomas. We report a 34-year-old male patient initially diagnosed with IDH-mu- tant grade 2 astrocytoma according to the 2021 WHO classification of CNS tumors. As the first surgi- cal resection achieved gross total resection on postoperative MRI, no adjuvant therapy was given and regular follow-up was planned. On 1-year follow-up MRI, two new enhancing nodular lesions appeared at the ipsilateral brain parenchyma abutting the surgical resection cavity. Salvage craniotomy achieved gross total resection, and the pathologic diagnosis was IDH-mutant WHO grade 4 astrocytoma. We describe this tumor in terms of the previous WHO classification to evaluate the risk of high-grade transformation and discuss possible risk factors leading to high-grade transformation of low-grade as- trocytoma.
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