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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한자기공명의과학회 Investigative Magnetic Resonance Imaging Investigative Magnetic Resonance Imaging 제19권 제4호
- 발행연도
- 2015.1
- 수록면
- 218 - 223 (6page)
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Purpose: To investigate whether volumetric analysis based on T2WI and contrastenhanced(CE) T1WI can distinguish between isocitrate dehydrogenase-1 mutationpositive(IDH1P) and -negative (IDH1N) glioblastomas (GBMs).
Materials and Methods: We retrospectively enrolled 109 patients with histopathologicallyproven GBMs after surgery or stereotactic biopsy and preoperative MR imaging.
We measured the whole-tumor volume in each patient using a semiautomaticsegmentation method based on both T2WI and CE T1WI. We compared the tumorvolumes between IDH1P (n = 12) and IDH1N (n = 97) GBMs using an unpaired t-test.
In addition, we performed receiver operating characteristic (ROC) analysis for thedifferentiation of IDH1P and IDH1N GBMs using the tumor volumes based on T2WIand CE T1WI.
Results: The mean tumor volume based on T2WI was larger for IDH1P GBMs thanIDH1N GBMs (108.8 ± 68.1 and 59.3 ± 37.3 mm3, respectively, P = 0.0002). Inaddition, IDH1P GBMs had a larger tumor volume on CE T1WI than did IDH1N tumors(49.00 ± 40.14 and 22.53 ± 17.51 mm3, respectively, P < 0.0001). ROC analysisrevealed that the tumor volume based on T2WI could distinguish IDH1P from IDH1Nwith a cutoff value of 90.25 (P < 0.05): 7 of 12 IDH1P (58.3%) and 79 of 97 IDH1N(81.4%).
Conclusion: Volumetric analysis of T2WI and CE T1WI could enable IDH1P GBMs tobe distinguished from IDH1N GBMs. We assumed that secondary GBMs with IDH1Punderwent stepwise progression and were more infiltrative than those with IDH1N,which might have resulted in the differences in tumor volume.
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참고문헌 (23)
참고문헌 신청
Aghi M / 2005 / Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastoma / Clin Cancer Res 11 : 8600 ~ 8605
Andronesi OC / 2013 / Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate / J Clin Invest 123 : 3659 ~ 3663
Balss J / 2008 / Analysis of the IDH1 codon 132 mutation in brain tumors / Acta Neuropathol 116 : 597 ~ 602
Carrillo JA / 2012 / Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma / AJNR Am J Neuroradiol 3
Choi C / 2012 / 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDHmutated patients with gliomas / Nat Med 18 : 624 ~ 629
Andronesi OC / 2013 / Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate / J Clin Invest 123 : 3659 ~ 3663
Balss J / 2008 / Analysis of the IDH1 codon 132 mutation in brain tumors / Acta Neuropathol 116 : 597 ~ 602
Carrillo JA / 2012 / Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma / AJNR Am J Neuroradiol 3
Choi C / 2012 / 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDHmutated patients with gliomas / Nat Med 18 : 624 ~ 629
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