Altered Expression of Oxidative Metabolism Related Genes in Cholangiocarcinomas

Aukkanimart, Ratchadawan; Boonmars, Thidarut; Juasook, Amornrat; Sriraj, Pranee; Boonjaraspinyo, Sirintip; Wu, Zhiliang; Laummuanwai, Porntip; Pairojkul, Chawalit; Khuntikeo, Narong; Rattanasuwan, Panaratana

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자료유형: 학술저널

저자정보: Aukkanimart, Ratchadawan (Department of Parasitology, Faculty of Medicine, Khon Kaen University) Boonmars, Thidarut (Department of Parasitology, Faculty of Medicine, Khon Kaen University) Juasook, Amornrat (Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University) Sriraj, Pranee (Department of Parasitology, Faculty of Medicine, Khon Kaen University) Boonjaraspinyo, Sirintip (Department of Parasitology, Faculty of Medicine, Khon Kaen University) Wu, Zhiliang (Department of Parasitology, Graduate School of Medicine, Gifu University) Laummuanwai, Porntip (Department of Parasitology, Faculty of Medicine, Khon Kaen University) Pairojkul, Chawalit (Department of Pathology, Faculty of Medicine, Khon Kaen University) Khuntikeo, Narong (Department of Surgery, Faculty of Medicine, Khon Kaen University) Rattanasuwan, Panaratana (Department of Anesthesiology, Faculty of Medicine, Khon Kaen University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제14호

발행연도: 2015.1

수록면: 5,875 - 5,881 (7page)

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Cholangiocarcinoma (CCA) is a rare but highly fatal cancer for which the molecular mechanisms and diagnostic markers are obscure. We therefore investigated the kinetic expression of isocitrate dehydrogenase-1 (IDH1), isocitrate dehydrogenase-2 (IDH2) and homogentisate 1,2-dioxygenase (HGD) during the tumorigenesis of O. viverrini infection-associated CCA in an animal model, and confirmed down-regulation of expression in human cases of opisthorchiasis-associated CCA through real time PCR. Kinetic expression of HGD, IDH1 and IDH2 in the animal model of O. viverrini infection-induced CCA was correlated with human CCA cases. In the animal model, expression of HGD was decreased at all time points (p<0.01) and expression of both IDH1 and IDH2 was decreased in the CCA group. In human cases, expression of HGD, IDH1 and IDH2 was decreased more than 2 fold in 55 cases (70.5%), 25 cases (32.1%) and 24 cases (30.8%) respectively. The present study suggests that reduction of HGD, IDH1 and IDH2 may be involve in cholangiocarcinoma genesis and may be useful for molecular diagnosis.

#Liver fluke #cholangiocarcinogenesis #IDH1) #IDH2 #HGD) #oxidative metabolism related genes

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Aukkanimart, Ratchadawan

소속기관 Neglected and Vector Borne-Zoonosis Research Group, Liver Fluke and Cholangiocarcinoma Research Cent