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논문 기본 정보

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저자정보
Young Eun Chon (Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam) Mina Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul) Dong Yun Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul) Mi Na Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea) Beom Kyung Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul; Institute of Gastroenterology, Yonsei University College of Medicine, Seoul; Yonsei Liver Center, Severance Hos) Seung Up Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul; Yonsei Liver Center, Severance Hospital, Seoul, Korea) Jun Yong Park (Department of Internal Medicine, Yonsei University College of Medicine, Seoul) Sang Hoon Ahn (Department of Internal Medicine, Yonsei University College of Medicine, Seoul) Yeonjung Ha (Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam) Joo Ho Lee (Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam) Kwan Sik Lee (Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam) Beodeul Kang (Department of Medical Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Korea) Jung Sun Kim (Department of Medical Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Korea) Hong Jae Chon (Department of Medical Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Korea) Do Young Kim (Department of Internal Medicine, Yonsei University College of Medicine, Seoul)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.30 No.3
발행연도
2024.7
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345 - 359 (15page)

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Background/Aims: Atezolizumab plus bevacizumab (ATE+BEV) therapy has become the recommended first-line therapy for patients with unresectable hepatocellular carcinoma (HCC) because of favorable treatment responses. However, there is a lack of data on sequential regimens after ATE+BEV treatment failure. We aimed to investigate the clinical outcomes of patients with advanced HCC who received subsequent systemic therapy for disease progression after ATE+BEV. Methods: This multicenter, retrospective study included patients who started second-line systemic treatment with sorafenib or lenvatinib after HCC progressed on ATE+BEV between August 2019 and December 2022. Treatment response was assessed using the Response Evaluation Criteria in Solid Tumors (version 1.1.). Clinical features of the two groups were balanced through propensity score (PS) matching. Results: This study enrolled 126 patients, 40 (31.7%) in the lenvatinib group, and 86 (68.3%) in the sorafenib group. The median age was 63 years, and males were predominant (88.1%). In PS-matched cohorts (36 patients in each group), the objective response rate was similar between the lenvatinib- and sorafenib-treated groups (5.6% vs. 8.3%; P=0.643), but the disease control rate was superior in the lenvatinib group (66.7% vs. 22.2%; P<0.001). Despite the superior progression-free survival (PFS) in the lenvatinib group (3.5 vs. 1.8 months, P=0.001), the overall survival (OS, 10.3 vs. 7.5 months, P=0.353) did not differ between the two PS-matched treatment groups. Conclusions: In second-line therapy for unresectable HCC after ATE+BEV failure, lenvatinib showed better PFS and comparable OS to sorafenib in a real-world setting. Future studies with larger sample sizes and longer followups are needed to optimize second-line treatment.
#Atezolizumab #Bevacizumab #Hepatocellular carcinoma #Lenvatinib #Sorafenib

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