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학술저널
저자정보
Kim, Shin Young (Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) Kim, Hee Yeon (Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) Kim, Yu Seung (Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) Lee, Sang Min (Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) Kim, Chang Wook (Division of Hepatology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
저널정보
영남대학교 의과대학 영남의대학술지 영남의대학술지 제32권 제1호
발행연도
2015.1
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47 - 49 (3page)

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Sorafenib is indicated for the treatment of advanced hepatocellular carcinoma (HCC), but although rare, tumor lysis syndrome (TLS) can be fatal in HCC patients with a large tumor burden. The authors describe the case of a 55-year-old hepatitis B carrier who visited our clinic with progressive dyspnea for 3 weeks. Chest and abdominal computed tomography revealed a huge HCC in the left lobe of the liver with invasion of the inferior vena cava, right atrium, and pulmonary arteries. After 8 days of sorafenib administration, TLS was diagnosed based on the characteristic findings of hyperuricemia, hyperkalemia, and acute kidney injury with massive tumor necrosis by follow-up imaging. Despite discontinuation of sorafenib and supportive care, the patient's clinical course rapidly deteriorated. The authors describe a rare but fatal complication that occurred soon after sorafenib initiation for HCC. Careful follow-up is required after commencing sorafenib therapy for the early diagnosis and management of TLS.

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