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학술저널
저자정보
전영은 (차의과학대학교) Han Ah Lee (Korea University College of Medicine) Jun Sik Yoon (Inje University) 박준용 (연세대학교) Bo Hyun Kim (National Cancer Center) In Joon Lee (National Cancer Center) Suk Kyun Hong (Seoul National University) Dong Hyeon Lee (Seoul Metropolitan Government Seoul National University Boramae Medical Center) Hyun-Joo Kong (National Cancer Center) Eunyang Kim (National Cancer Center) Young-Joo Won (National Cancer Center) Jeong Hoon Lee (Seoul National University)
저널정보
대한간암학회 Journal of Liver Cancer Journal of Liver Cancer Vol.20 No.2
발행연도
2020.1
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135 - 147 (13page)

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Background/Aims: Considering the high prevalence and mortality of hepatocellular carcinoma (HCC) in Korea, accurate statistics for HCC are important. We evaluated the characteristics of Korean patients with newly diagnosed HCC. Methods: We retrospectively evaluated data from the Korean Primary Liver Cancer Registry (KPLCR). The baseline characteristics, treatment modalities, and overall survival (OS) of 4,572 patients with HCC registered in the KPLCR between 2012 and 2014 were investigated. Results: At the time of HCC diagnosis, the median age was 60.0 years, with male predominance (79.6%). Hepatitis B virus infection was the most common etiology (59.1%). The rates of Barcelona Clinic Liver Cancer (BCLC) stages 0, A, B, C, and D at diagnosis were 3.9%, 36.9%, 12.5%, 39.4%, and 7.3%, respectively. The proportion of very early or early stage HCC at diagnosis (BCLC stage 0 or A) in the 2012-2014 cohort was significantly lower than that in the 2008-2011 cohort (40.8%vs. 48.3%, P<0.001). Transarterial therapy (37.5%) was the most commonly performed initial treatment, followed by surgical resection (19.8%), best supportive care (19.1%), and local ablation (10.6%). The median OS was 2.9 years, and the 1-, 3-, and 5-year OS rates were 67.7%, 49.3% and 41.9%, respectively. The OS rate of the 2012-2014 cohort was significantly higher than that of the 2008-2011 cohort (log-rank, P<0.001). Conclusions: The OS of HCC patients registered in the KPLCR between 2012 and 2014 significantly improved. Nevertheless, as about half of the HCC patients were diagnosed at an advanced stage, vigorous and optimized HCC screening strategies should be implemented.

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