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논문 기본 정보

자료유형
학술저널
저자정보
Diyang Xie (Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Fudan University) Jieyi Shi (Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Fudan University) Jian Zhou (Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Fudan University; Institute of Biomedical Sciences Fudan University) Jia Fan (Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Fudan University; Institute of Biomedical Sciences Fudan University) Qiang Gao (Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Fudan University)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology 제29권 제2호
발행연도
2023.4
수록면
206 - 216 (11page)

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Liver cancer is the fourth most prevalent and the second most lethal cancer in China. Hepatitis B virus (HBV) infection represents a major risk factor for hepatocellular carcinoma (HCC). Liver ultrasonography plus alpha-fetoprotein every 6 months continues to be the predominant surveillance modality. The age-Male-ALBI-Platelets score was recommended in the recent 2022 Chinese guidelines to predict HCC occurrence. The Chinese liver cancer (CNLC) staging system proposed in the 2017 guidelines continues to be the standard model for staging with modifications in the treatment allocations. Considering the aggressive nature of HBV-associated HCC, multimodal and high-intensity strategies like the addition of immunotherapy-based systemic treatment to local therapies, including resection, ablation, and intra-arterial therapies, have been adopted in real-life practices in China. The latest Chinese guidelines recommend atezolizumab plus bevacizumab, suntilimab plus a bevacizumab analog, lenvatinib, sorafenib, donafenib, and FOLFOX (folinic acid, fluorouracil, and oxaliplatin) chemotherapy as first-line treatment without priority. Regorafenib, apatinib, camrelizumab, and tislelizumab have been added as second-line systemic therapies for patients who progressed on sorafenib. Systemic therapies adopted in real-life practice are sophisticated with various combination modalities and different sequences.

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