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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 14 - 28 (15page)
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Diet-induced gastrointestinal dysbiosis has been hypothesized to play a significant role in stimulating an increase ingastrointestinal permeability and activating systemic inflammation in women with polycystic ovary syndrome (PCOS).
We reviewed the current proof-of-concept studies on the proposed mechanism of dysbiosis in the pathogenesis ofPCOS. A literature search was performed to identify articles on changes in the intestinal microbiome (dysbiosis) andincreased intestinal mucosal permeability involving lipopolysaccharide (LPS), LPS-binding protein (LPS-BP), and zonulin.
We also searched for systematic reviews and meta-analyses that synthesized the results of studies on the therapeuticeffects of prebiotics, probiotics, or synbiotics in women with PCOS. Our search was confined to human studiesbetween 2012 and 2021 using the PubMed, Scopus, and Cochrane databases. Thirty-one studies met the inclusioncriteria (14 microbiota, 1 LPS, 1 LPS-BP, 1 LPS and LPS-BP, 5 zonulin, 9 systematic reviews). Our analysis revealed thatmost studies reported reduced alpha diversity and dysbiosis in women with PCOS. Preliminary studies suggest that LPS,LPS-BP, and zonulin may be involved in the pathophysiology of increased intestinal permeability. Treatment of PCOSwith prebiotics, probiotics, and synbiotics appears to have a range of beneficial effects on metabolic and biochemicalprofiles. This review highlights the need for continued research into the pathophysiological mechanisms of dysbiosisand the clinical efficacy of prebiotics, probiotics, and synbiotics in women with PCOS.
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