지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
- 수록면
- 1 - 13 (13page)
- DOI
- 10.1016/j.mocell.2024.100125
이용수
초록· 키워드
오류제보하기
FAM19A5 is a novel secretory protein expressed primarily in the brain. However, a recent study reported that FAM19A5 is an adipocyte-derived adipokine that regulates vascular smooth muscle function through sphingosine-1-phosphate receptor 2 (S1PR2). In our study, we investigated FAM19A5 transcript and protein levels in peripheral tissues, including adipose tissues, from wild-type, FAM19A5 knockout, and FAM19A5-LacZ knockin mice. We found that the FAM19A5 transcript levels in the central nervous system were much greater than those in any of the peripheral tissues, including adipose tissues. Furthermore, the FAM19A5 protein levels in adipose and reproductive tissues were below detectable limits for Western blot analysis and enzyme-linked immunosorbent assay (ELISA). Additionally, we found that the FAM19A5 protein did not interact with S1PR2 in terms of G-protein-mediated signal transduction, β-arrestin recruitment, or ligand-mediated internalization. Taken together, our findings revealed basal levels of FAM19A5 transcripts and proteins in peripheral tissues, confirming its primary expression in the central nervous system and lack of significant interaction with S1PR2.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Functional evaluation of alternative splicing in the FAM190A gene
Genes & Genomics
2019 .01
-
Mesenchymal-to-epithelial transition of osteoblasts induced by Fam20c knockout
Genes & Genomics
2022 .02
-
Development of Wound Dressing based on Fish Acellular Matrix
한국해양바이오학회지
2024 .12
-
비만에서 adipose tissue 호르몬에 의한 metabolic signaling
생명과학회지
2023 .03
-
Assessment of The Accuracy of The MR Abdominal Adipose Tissue Volumetry using 3D Gradient Dual Echo 2-Point DIXON Technique using CT as Reference
Journal of Magnetics
2016 .12
-
Sensory nerve and neuropeptide diversity in adipose tissues
Molecules and Cells
2024 .01
-
On the Convergence of an Optimization Algorithm Based on Nonlinear Operators
East Asian Mathematical Journal
2020 .01
-
A novel nonsense mutation in NPR2 gene causing Acromesomelic dysplasia, type Maroteaux in a consanguineous family in Southern Punjab (Pakistan)
Genes & Genomics
2020 .01
-
Abyssanaerobacter marinus gen. nov., sp. nov., γ-Aminobutyrate-fermenting, Anaerobic Bacterium Isolated from the Onnuri Vent Field of the Indian Ocean and Suggestion of Clostridiales Family XIII Insertae Sedis Emended Mogibacteriaceae fam. nov., Proposal for Phylogenetically Reclassification of Ambiguous This Family’s Genus Member
한국미생물학회 학술대회논문집
2021 .08
-
Shall We Begin the Voyage of Adipose Tissue Exploration?
Molecules and Cells
2022 .06
-
The Role of Splicing Factors in Adipogenesis and Thermogenesis
Molecules and Cells
2023 .05
-
Analysis of lipid remodeling in adipose tissue
한국분석과학회 학술대회
2021 .05
-
Vitamin D regulation of adipogenesis and adipose tissue functions
Nutrition Research and Practice
2020 .12
-
Vitamin D regulation of adipogenesis and adipose tissue functions
Nutrition Research and Practice
2020 .12
-
Lipogenesis와 adipose expansion의 전사조절
생명과학회지
2022 .04
-
Whole genome sequencing of mouse lines divergently selected for fatness (FLI) and leanness (FHI) revealed several genetic variants as candidates for novel obesity genes
Genes & Genomics
2024 .05
-
Inhibitory effects of Doenjang, Korean traditional fermented soybean paste, on oxidative stress and inflammation in adipose tissue of mice fed a high-fat diet
Nutrition Research and Practice
2015 .06
-
Inhibitory effects of Doenjang, Korean traditional fermented soybean paste, on oxidative stress and inflammation in adipose tissue of mice fed a high-fat diet
Nutrition Research and Practice
2015 .06
-
Comparative Analyses of Tomato yellow leaf curl virus C4 Protein-Interacting Host Proteins in Healthy and Infected Tomato Tissues
The Plant Pathology Journal
2016 .10
최근 본 자료
댓글(0)
0