지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 2,082 - 2,095 (14page)
- DOI
- 10.1038/s12276-024-01320-0
이용수
초록· 키워드
오류제보하기
Patients with lung adenocarcinoma who have never smoked (NSLA) and lack key driver mutations, such as those in the EGFR and ALK genes, face limited options for targeted therapies. They also tend to have poorer outcomes with immune checkpoint inhibitors than lung cancer patients who have a history of smoking. The proteogenomic profile of nonsmoking lung adenocarcinoma patients without these oncogenic driver mutations is poorly understood, which complicates the precise molecular classification of these cancers and highlights a significant area of unmet clinical need. This study analyzed the genome, transcriptome, and LC‒MS/MS-TMT-driven proteome data of tumors obtained from 99 Korean never-smoker lung adenocarcinoma patients. NSLA tumors without EGFR or ALK driver oncogenes were classified into four proteogenomic subgroups: proliferation, angiogenesis, immune, and metabolism subgroups. These 4 molecular subgroups were strongly associated with distinct clinical outcomes. The proliferation and angiogenesis subtypes were associated with a poorer prognosis, while the immune subtype was associated with the most favorable outcome, which was validated in an external lung cancer dataset. Genomic-wide impacts were analyzed, and significant correlations were found between copy number alterations and both the transcriptome and proteome for several genes, with enrichment in the ERBB, neurotrophin, insulin, and MAPK signaling pathways. Proteogenomic analyses suggested several targetable genes and proteins, including CDKs and ATR, as potential therapeutic targets in the proliferation subgroup. Upregulated cytokines, such as CCL5 and CXCL13, in the immune subgroup may serve as potential targets for combination immunotherapy. Our comprehensive proteogenomic analysis revealed the molecular subtypes of EGFR- and ALK-wild-type NSLA with significant unmet clinical needs.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective
BMB Reports
2020 .01
-
Dual effects of a CpG-DNAzyme targeting mutant EGFR transcripts in lung cancer cells: TLR9 activation and EGFR downregulation
BMB Reports
2018 .01
-
비소세포폐암 EGFR유전자 변이 검출용 액체생검 카트리지 및 사출 금형 설계 기술 개발
한국소성가공학회 학술대회 논문집
2023 .11
-
Fluorometric Detection of Oncogenic EML4-ALK Fusion Gene based on a Graphene Oxide System
BioChip Journal
2019 .01
-
Survival Time Analysis of Lung Adenocarcinoma from Colon Cancer by Using Pathology images
한국정보과학회 학술발표논문집
2021 .06
-
An Application of Maximality to Nilpotent and Finitely Generated L-Subgroups of an L-Group
INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGENT SYSTEMS
2023 .03
-
Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer
Experimental and Molecular Medicine
2024 .05
-
Extraction of Lung Tumor Regions from Thoracic CT Images Using An Improved U-Net
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
The study on survivability of Korean-American Lung cancer patients in SEER data with Kaplan Meier Method
대한인간공학회 학술대회논문집
2015 .10
-
Beyond EGFR inhibition: multilateral combat strategies to stop the progression of head and neck cancer
Experimental and Molecular Medicine
2019 .01
-
딥러닝을 활용한 멀티모달 CT의 2D 조인트 히스토그램 기반 폐암 종류 분류
대한전자공학회 학술대회
2018 .06
-
Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway
BMB Reports
2024 .07
-
Classification of Driver Gene Mutations from 3D-CT Images Based on Radiomics Features
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Experimental and Molecular Medicine
2021 .01
-
A Short Linear Motif Peptide Targeting Human Lung Adenocarcinoma
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
내부 디스정션 표현이 가능한 서브그룹 규칙 학습 방법
한국컴퓨터정보학회논문지
2017 .01
-
Classification of histological types of primary lung cancer from CT images using clinical information
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells
BMB Reports
2018 .01
최근 본 자료
댓글(0)
0