지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 642 - 647 (6page)
이용수
초록· 키워드
오류제보하기
Ubiquitin-conjugating enzyme E2S (UBE2S), a family of E2 protein in the ubiquitination process, is involved in development of various cancers. However, its role in lung adenocarcinoma, has not been well elucidated. In this report, we attempted to investigate expression and function of UBE2S in lung adenocarcinoma. Up-regulation of UBE2S at mRNA, and protein level, was observed in human cancer tissues and lung adenocarcinoma cells. Higher UBE2S expression correlated with poorer prognosis of lung adenocarcinoma patients. UBE2S expression was efficiently suppressed by lentivirus-mediated shRNA strategy in A549 cells, and UBE2S silencing led to reduced cell proliferation, colony formation, and enhanced apoptosis. Inverse results were observed, in UBE2S over-expressed H1299 cells. Microarray analysis indicated that a large number of genes were regulated by UBE2S, and p53 signaling pathway may be critical, to the role of UBE2S in cancer development. Together, UBE2S could be a potential target for lung adenocarcinoma.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Jemal A / 2002 / Cancer statistics, 2002 / CA Cancer J Clin 52:23~47
Imielinski M / 2012 / Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing / Cell 150:1107~1120
McGuire S / 2015 / World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer :418~419
Alberg AJ / 2013 / Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines / Chest 143:e1S~e29S
Paul A / 2017 / RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage / Mol Cell 66:458~472e455
Imielinski M / 2012 / Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing / Cell 150:1107~1120
McGuire S / 2015 / World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer :418~419
Alberg AJ / 2013 / Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines / Chest 143:e1S~e29S
Paul A / 2017 / RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage / Mol Cell 66:458~472e455
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
해외건축동향: 일본 - 지방도시의 지역재생을 위한 새로운 시도와 「학(學)」의 역할 _ 우베(宇部)시 와카모노(若者) 크리에이티브 컨테이너
건축사
2017 .01
-
초내열강 몰리브덴합금 Target 성형소결특성
한국기계가공학회 춘추계학술대회 논문집
2018 .04
-
A Short Linear Motif Peptide Targeting Human Lung Adenocarcinoma
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity
Experimental and Molecular Medicine
2016 .01
-
Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomics
Experimental and Molecular Medicine
2022 .11
-
Survival Time Analysis of Lung Adenocarcinoma from Colon Cancer by Using Pathology images
한국정보과학회 학술발표논문집
2021 .06
-
Novel discrimination system for lung cancer cell with virus based color structure
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
The study on survivability of Korean-American Lung cancer patients in SEER data with Kaplan Meier Method
대한인간공학회 학술대회논문집
2015 .10
-
Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Experimental and Molecular Medicine
2021 .01
-
Proteogenomic characterization identifies clinical subgroups in EGFR and ALK wild-type never-smoker lung adenocarcinoma
Experimental and Molecular Medicine
2024 .09
-
Screening of Medicinal Plants as an Anti-cancer Agent in Lung Adenocarcinoma and Skin Melanoma Cells
한국생물공학회 학술대회
2021 .04
-
GPR78 promotes lung cancer cell migration and metastasis by activation of Gq-Rho GTPase pathway
BMB Reports
2016 .01
-
Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation
Experimental and Molecular Medicine
2021 .10
-
비소세포 폐암 병기 예측을 위한 전이 학습 및 임상 변수 활용
대한전자공학회 학술대회
2021 .06
-
Extraction of Lung Tumor Regions from Thoracic CT Images Using An Improved U-Net
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
Classification of histological types of primary lung cancer from CT images using clinical information
제어로봇시스템학회 국제학술대회 논문집
2023 .10
-
미세먼지 매개 폐질환 연구를 위한 오가노이드 모델 활용
Journal of the Environment
2024 .06
-
A Fully-Human Antibody Specifically Targeting a Membrane-Bound Fragment of CADM1 Potentiates the T Cell-Mediated Death of Human Small-Cell Lung Cancer Cells
한국생물공학회 학술대회
2023 .04
-
Histological and Physiological Studies of the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Bleomycin Induced Lung Fibrosis in Adult Albino Rats
조직공학과 재생의학
2021 .01
-
Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response
Experimental and Molecular Medicine
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0