지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 298 - 305 (8page)
이용수
초록· 키워드
오류제보하기
Objectives: Hyperlipidemia is a metabolic syndrome in which lipid or lipoprotein levels in the blood increase due to metabolic and functional abnormalities of fat. Excessive adipocyte hypertrophy causes cellular organ dysfunction, hormonal dysregulation, fatty acid storage disorders, and lipotoxicity to non-fat tissue organs such as the liver, muscles, and pancreas.
STON1 has recently been proposed as a protein-coding gene involved in the intracellular tissue and metabolic process of adipocytes, which is characterized by high expression in adipose tissue. In this study, the correlation between the STON1 and hyperlipidemia was analyzed.
Methods: Genetic polymorphisms of STON1 were investigated using Korean genomic and epidemiological data. A gene association study was performed using PLINK version 1.07. Other statistical analyses were performed using PASW Statistics version 18.0.
Results: The genetic polymorphisms in the STON1 gene were analyzed in 181 hyperlipidemia patients and 7,547 healthy controls in Korean. As a result, 4 single nucleotide polymorphisms (SNPs) showed statistical significance ( P < 0.05) in the genotype, 33 SNPs showed a significant correlation after imputation, and the relative risk of hyperlipidemia was low. Among them, rs3792234 of STON1 showed the highest significant association with hyperlipidemia ( P-value = 6 × 10-4, odds ratio = 0.67, 95% confidence interval = 0.53–0.84). The genotype-based mRNA expression analysis showed that the group of minor alleles of rs3792234 showed decreased mRNA expression.
Conclusion: Polymorphism in STON1 is associated with the development of hyperlipidemia, which may provide a basis for new guidelines for the management of hyperlipidemia in the Korean population.
STON1 has recently been proposed as a protein-coding gene involved in the intracellular tissue and metabolic process of adipocytes, which is characterized by high expression in adipose tissue. In this study, the correlation between the STON1 and hyperlipidemia was analyzed.
Methods: Genetic polymorphisms of STON1 were investigated using Korean genomic and epidemiological data. A gene association study was performed using PLINK version 1.07. Other statistical analyses were performed using PASW Statistics version 18.0.
Results: The genetic polymorphisms in the STON1 gene were analyzed in 181 hyperlipidemia patients and 7,547 healthy controls in Korean. As a result, 4 single nucleotide polymorphisms (SNPs) showed statistical significance ( P < 0.05) in the genotype, 33 SNPs showed a significant correlation after imputation, and the relative risk of hyperlipidemia was low. Among them, rs3792234 of STON1 showed the highest significant association with hyperlipidemia ( P-value = 6 × 10-4, odds ratio = 0.67, 95% confidence interval = 0.53–0.84). The genotype-based mRNA expression analysis showed that the group of minor alleles of rs3792234 showed decreased mRNA expression.
Conclusion: Polymorphism in STON1 is associated with the development of hyperlipidemia, which may provide a basis for new guidelines for the management of hyperlipidemia in the Korean population.
목차
ABSTRACT
ABSTRACT
서론
재료 및 방법
서론
결과
재료 및 방법
논의
결과
REFERENCES
논의
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hyperlipidemia as a predictor of physical functioning for stroke
Physical therapy rehabilitation science
2018 .01
-
Influence of Hyperlipidemia on the Treatment of Supraspinatus Tendinopathy With or Without Tear
Annals of Rehabilitation Medicine
2016 .01
-
고지혈증 환자에서 만성 비부비동염의 유병률 및 위험인자 분석
대한이비인후-두경부외과학회지
2015 .01
-
Comparison of the response using ICR mice derived from three different sources to high fat diet-induced hyperlipidemia
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Attenuation of hyperglycemia and hyperlipidemia in Diet-induced Metabolic Disease animal model by unripe Rubus occidentalis
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Antioxidant and hepatoprotective effect of fermented red ginseng against liver injury in hyperlipidemia rats
한국실험동물학회 학술발표대회 논문집
2015 .02
-
A Case Study on the Improvement of Hyperlipidemia Patients Using Ortho-Cellular Nutrition Therapy (OCNT)
셀메드
2023 .07
-
Effect of extract composed of husks and cobs from purple corn on the triton WR 1339 induced hyperlipidemia in rats
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats.
한국실험동물학회 학술발표대회 논문집
2017 .02
-
제조방법을 달리한 경옥고의 고콜레스테롤혈증 흰쥐에 미치는 효능 비교 연구
대한본초학회지(본초분과학회지)
2017 .01
-
Restoration of Declined Immune Responses and Hyperlipidemia by Rubus occidenalis in Diet-Induced Obese Mice
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Effect of ethanol extract from Ligularia fischeri on hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet
한국실험동물학회 학술발표대회 논문집
2016 .02
-
An optimized herbal medicine HTB attenuates hyperlipidemia by activating the AMPK/SREBP2/PCSK9 signaling pathway
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Association Study between Norepinephrine Transporter Gene Polymorphism and Schizophrenia in a Korean Population
PSYCHIATRY INVESTIGATION
2015 .01
-
Molecular Effects of Hyperlipidemia on Vascular Endothelial Cells in Patients with Diabetic Nephropathy Using Human Vascular Tissues
대한외과학회 학술대회 초록집
2023 .05
-
Evaluation of Bone Density Measurement in Type 2 Diabetic Postmenopausal Women with Hypertension and Hyperlipidemia
대한폐경학회지
2015 .01
-
Protective Effect of Mulberry Leaf and Yacon Extract Induced Hyperlipidemia in Obese Rats
대한의생명과학회지
2020 .06
-
Systematic Evaluation and Meta-Analysis of the Effect of Gynostemma pentaphyllum on Clinical Indexes of Hyperlipidemia
Natural Product Sciences
2023 .12
-
Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis
Journal of Ginseng Research
2022 .03
-
Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran
Diabetes and Metabolism Journal
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-092173735