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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 101 - 108 (8page)
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초록· 키워드
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There has been a lot of interest in medicinal effects for hyperlipidemia from the natural product since the therapy of atherosclerosis has emerged as social concern. Rats were acclimated to the feeding environment for one week and induced to obesity with high fat diet during 4 weeks until their body weight were more than 30% of normal range. To evaluate the effect of hyperlipidemia of mulberry leaf of Morus alba and yacon tuber of Smallanthus sonchifolia extracts (MLYT), 1%, 3%, 5% of MLYT were treated to Sprague-Dawley rats. Aspartate transaminase (AST) was significantly increased 26.2% in high fat diet group (G2) compared to normal diet group (G1) (P<0.05). But AST were significantly decreased in high fat diet with 0.5% hydroxycitric acid diet group (G3) and all the MLYT treated groups compared to G2. Total cholesterol, low-density lipoprotein (LDL), triglycerides and phospholipids were observed significant improvements in the MLYT-treated groups (P<0.05). These improvements in liver and feces were further supported by the lipid content. MLYT remarkably suppressed the level of lipid peroxidation caused by high-fat diet in rats. The level of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase activity. As a result, the proper combination of mulberry leaves and yacon tuber extract will have a synergistic effect on hyperlipidemia. These results indicate that MLYT could be a candidate for the improvement of hyperlipidemia.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
Alvarez FPP / 2008 / Prebiotic inulin/oligofructose in yacon root(Smallanthus sonchifolius), phytochemistry and standardization as basis for clinical and preclinical research / Rev Gastroenterol Peru 28:22~27
Asami T / 1989 / Chemical composition of yacon, a new root crop from Andean highland / Jpn J Soli Sci Plant Nutr 60:122~126
Biggs HG / 1975 / A manual colorimetric assay of triglyceride in serum / Clin Chem 21:437~441
Carroll MD / 2017 / Total and High-density Lipoprotein Cholesterol in Adults : United States, 2015-2016 / NCHS Data Brief 290:1~8
Chen HL / 2000 / Effects of fructooligosaccharide on bowel function and indicators of nutritional status in constipated elderly men / Nutr Res 20:1725~1733
Asami T / 1989 / Chemical composition of yacon, a new root crop from Andean highland / Jpn J Soli Sci Plant Nutr 60:122~126
Biggs HG / 1975 / A manual colorimetric assay of triglyceride in serum / Clin Chem 21:437~441
Carroll MD / 2017 / Total and High-density Lipoprotein Cholesterol in Adults : United States, 2015-2016 / NCHS Data Brief 290:1~8
Chen HL / 2000 / Effects of fructooligosaccharide on bowel function and indicators of nutritional status in constipated elderly men / Nutr Res 20:1725~1733
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UCI(KEPA) : I410-ECN-0101-2020-510-000849657