고지혈증 환자에서 만성 비부비동염의 유병률 및 위험인자 분석

이은정; 김지훈; 서연석; 최병일; 정찬민; 김경수

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자료유형: 학술저널

저자정보: 이은정 김지훈 서연석 최병일 정찬민 김경수

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제58권 제1호

발행연도: 2015.1

수록면: 25 - 31 (7page)

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Background and Objectives According to previous studies, acute and chronic cholesterol depletion in the cell membranes of human airway epithelial cells suppresses MUC5AC gene expression. Also statins and lipid-lowering drugs are known to have anti-inflammatory effects. From these results, we hypothesize that the use of statin decreases the prevalence of chronic rhinosinusitis (CRS). Therefore, this study aimed to analyze the correlation between hyperlipidemia and the use of statin and prevalence of CRS in Korea. Subjects and Method The data were based on the Korean National Health and Nutrition Examination Survey in 2010 and 2011. Symptom-based criteria of European Position Paper on Rhinosinusitis and Nasal Polyps 2012 were used to define CRS. 12000 people were enrolled in this study. Results The CRS prevalence of hyperlipidemia group (14.13%) was significantly higher than that of non-hyperlipidemia group (10.87%) (p=0.0005). However, the CRS prevalence between statin users (14.27%) and nonusers (13.94%) in hyperlipidemia group showed no significant differences. Thus, hyperlipidemia itself was a risk factor of CRS regardless of using statin. Allergic rhinitis was the only significant risk factor of CRS in hyperlipidemia group in multivariate regression analysis. Conclusion Hyperlipidemia patients who have allergic rhinitis are at risk of CRS regardless of whether they use statins; however, further study using objective data will be required to verify this result.

#Hyperlipidemia #Prevalence #Risk factor #Sinusitis

참고문헌 (25)

참고문헌 신청

Bachert C / 2002 / Allergic rhinitis and its impact on asthma. In collaboration with the World Health Organization. Executive summary of the workshop report. 7-10 December 19

Benninger MS / 2003 / Adult chronic rhinosinusitis: definitions, diagnosis, epidemiology, and pathophysiology / Otolaryngol Head Neck Surg 129 (3 Suppl) : S1 ~ S32

Berrettini S / 1999 / Perennial allergic rhinitis and chronic sinusitis:correlation with rhinologic risk factors / Allergy 54 (3) : 242 ~ 248

Bu DX / 2011 / Mechanisms for the anti-inflammatory effects of statins / Curr Opin Lipidol 22 (3) : 165 ~ 170

Emanuel IA / 2000 / Chronic rhinosinusitis: allergy and sinus computed tomography relationships / Otolaryngol Head Neck Surg 123 (6) : 687 ~ 691

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