Systematic Evaluation and Meta-Analysis of the Effect of Gynostemma pentaphyllum on Clinical Indexes of Hyperlipidemia

Hao-Tian Luo; Man-Yu Xiao; Wen-Jing Pei; Kang-Le Bi; Peng Xie; Yu-Long Gu; Xiang-Lan Piao

doi:10.20307/nps.2023.29.4.251

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자료유형: 학술저널

저자정보: Hao-Tian Luo (Minzu University of China) Man-Yu Xiao (Minzu University of China) Wen-Jing Pei (Minzu University of China) Kang-Le Bi (Minzu University of China) Peng Xie (Minzu University of China) Yu-Long Gu (Minzu University of China) Xiang-Lan Piao (Minzu University of China)

저널정보: 한국생약학회 Natural Product Sciences Natural Product Sciences Vol.29 No.4

발행연도: 2023.12

수록면: 251 - 265 (15page)

DOI: 10.20307/nps.2023.29.4.251

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The purpose of this study was to explore the clinical efficacy and safety of Gynostemma pentaphyllum (G. pentaphyllum) in the treatment of hyperlipidemia, and to provide systematic evaluation basis for clinical application. CNKI, Wanfang Data, VIP, Web of science, PubMed, Embase and Cochrane Library were searched for randomized controlled trials (RCTs) about G. pentaphyllum in the treatment of hyperlipidemia. Review Manager 5.4 were used for statistical analysis. Through reading topics, abstracts, and full texts, 27 papers with 2311 cases involved that met the inclusion and exclusion criteria were finally included for the analysis. In terms of curative effect, the effect of G. pentaphyllum alone in increasing high density lipoprotein (HDL) index was better than that of conventional treatment, and the effect of reducing total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) was similar to that of conventional treatment. There was a synergistic effect between G. pentaphyllum and conventional drugs, and the combination of G. pentaphyllum and conventional drugs was superior to conventional treatment in reducing TG and increasing HDL. G. pentaphyllum can also decrease the levels of serum glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in the treatment of hyperlipidemia, indicating a certain protective function of the liver. In terms of safety, there were fewer cases of adverse reactions in the G. pentaphyllum treatment group, and the adverse reaction events reported in the literature was mild. According to the results of meta-analysis, G. pentaphyllum was effective in the treatment of hyperlipidemia, and it has the potential to be combined with traditional drugs, has a certain liver protection function, and was superior to traditional drugs in the treatment of hyperlipidemia.

#Gynostemma pentaphyllum #Hyperlipidemia #Meta-analysis #Clinical evaluation

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