지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.8
- 수록면
- 590 - 600 (11page)
이용수
초록· 키워드
오류제보하기
Angelica keiskei, a perennial herb from Apiaceae family, has been reported to improve diabetes, inhibit thrombosis, alleviate dyslipidemia, and prevent type 2 diabetes, obesity, and atherosclerosis. In this study, the protective effects of A. keiskei extract (AKE) against tumor necrosis factor-alpha (TNF-α)-induced oxidative stress and vascular inflammation in human umbilical vein endothelial cells (HUVECs) were investigated through cell viability analysis, antioxidant enzyme analysis, western blotting, and immunofluorescence staining. The results demonstrated that pretreatment of Angelica keiskei with AKE significantly inhibited the expression of key adhesion molecules such as E-selectin, ICAM-1 and VCAM-1 induced by TNF-α. AKE also showed a substantial reduction in intracellular reactive oxygen species levels and an increase in antioxidant enzyme activity, indicating potential antioxidant capabilities. This study further explained that AKE interfered with the nuclear factor-kappa B (NF-κB) pathway by inhibiting phosphorylation of IκBα and NF-κB, thereby preventing nuclear translocation. Additionally, AKE selectively inhibited the activation of c-Jun N-terminal kinase (JNK) within the mitogen-activated protein kinase (MAPK) pathway, revealing a specific action mechanism. These findings collectively suggest that AKE possesses multi-faceted protective properties, making it a potential therapeutic agent for inflammatory conditions and early atherosclerosis.
목차
Abstract
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusions
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Angelica keiskei extract suppress VCAM-1 and ICAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation
한국식품영양과학회 학술대회발표집
2023 .10
-
혈관내피세포에서 TNF-α 자극에 의해 유도되는 혈관염증에 대한 전통식품 품질인증 된장의 효능 평가
Food Science and Preservation
2016 .06
-
The Influence of Storage Time and Temperature on the Activities of Antioxidant and Alcohol Metabolizing Enzyme of Heat-Treated Angelica keiskei/Green Grape/Pear Juice
한국식품영양과학회 학술대회발표집
2018 .10
-
Effects of Morus alba L. and Angelica keiskei on Dexamethasone-induced Skeletal Muscle Atrophy through Muscle Protein Metabolism
한국식품영양과학회 학술대회발표집
2022 .10
-
Hexane fraction from the ethanolic extract of Sargassum serratifolium suppresses cell adhesion molecules via regulation of NF-κB and Nrf2 pathway in human umbilical vein endothelial cells
Fisheries and Aquatic Sciences
2019 .01
-
Ethanolic extract from Sargassum serratifolium inhibits tumor necrosis factor-α-mediated vascular inflammation in human umbilical vein endothelial cells
한국수산과학회 양식분과 학술대회
2015 .10
-
Cirsium japonicum var. maackii Extract Suppress Vascular Adhesion Factor Expression in TNF-α-treated Human Vascular Endothelial Cells by Inhibiting NF-κB Activation
한국식품영양과학회 학술대회발표집
2022 .10
-
혈관내피세포에서 TNF-α로 유도되는 혈관염증에 대한 쏙(Upogebia major) 효소가수분해물의 억제 효과
한국수산과학회지
2018 .04
-
Antioxidant Effect of Ethanol Extract of Angelica gigas and Angelica acutiloba Seeds
한국식품영양과학회 학술대회발표집
2020 .10
-
Effect of Dietary Fiber Extracted from Algelica keiskei Koidz on the Quality Characteristics of Chicken Patties
한국축산식품학회지
2015 .01
-
A Study on Spicy Sauce Using Cheongyang Green Pepper Containing Angelica keiskei
한국식품영양과학회 학술대회발표집
2021 .10
-
SARGAQUINOIC ACID ISOLATED FROM Sargassium serratifolium INHIBITS TUMOR NECROSIS FACTOR-α-MEDIATED VASCULAR INFLAMMATION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
한국수산과학회 양식분과 학술대회
2015 .05
-
순무(Brassica rapa L.)의 TNF-α 자극에 의해 유도된 혈관염증 개선 효능
한국식품영양과학회지
2020 .02
-
The protective effect of fucoxanthin isolated from Ishige okamurae on oxidative stress induced by high glucose in human umbilical vein endothelial cells and zebrafish model
한국수산과학회 양식분과 학술대회
2018 .05
-
Phlorotannins from Ecklonia cava Attenuate Aβ25-35-Induced Neuroinflammation via Inhibiting NF-κB/MAPKs Pathway
한국식품영양과학회 학술대회발표집
2018 .10
-
Identification and protective mechanism of peptides from blue mussel (Mytilus edulis) in oxidative stress-mediated human umbilical vein endothelial cell injury
한국수산과학회 양식분과 학술대회
2020 .07
-
세발당귀(Angelica gigas Jiri)의 판별을 위한 ARMS-PCR용 분자표지 개발
Journal of Plant Biotechnology
2021 .01
-
Combined Extract of Vitis vinifera L. and Centella asiatica Synergistically Attenuates Oxidative Damage Induced by Hydrogen Peroxide in Human Umbilical Vein Endothelial Cells
Preventive Nutrition and Food Science
2020 .06
-
Korean Ginseng Extracts Prevent Hepatic Oxidative Stress and Inflammation Induced by Environmental Heat Stress
한국식품영양과학회 학술대회발표집
2018 .10
-
Effect of Angelica gigas Extracts on Antioxidant Activity and Differentiation of Osteoblastic MC3T3-E1 Cells
한국식품영양과학회 학술대회발표집
2016 .10
최근 본 자료
댓글(0)
0