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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.2
- 발행연도
- 2020.6
- 수록면
- 173 - 183 (11page)
- DOI
- 10.3746/pnf.2020.25.2.173
이용수
초록· 키워드
오류제보하기
Endothelial cell injury caused by oxidative stress is a critical factor in the initial stage of vascular diseases. Thus, identification of more effective antioxidants is a promising strategy to protect against endothelial cell injury. Recently, synergistic effects between phytochemicals have received renewed attention for their role in the treatment of various diseases. Vitis vinifera L. and Centella asiatica are well-known medicinal plants with various biological effects. However, the combination of the two has not previously been studied. Here, we investigated the effects of V. vinifera L. leaf and C. asiatica extract combination (VCEC), a standardized herbal blend comprising V. vinifera L. leaf extract (VE) and C. asiatica extract (CE), for its antioxidant activity and for the protection of endothelial cells against hydrogen peroxide (H₂O₂)-mediated oxidative damage in human umbilical vein endothelial cells (HUVECs). VCEC showed higher antioxidant activity than VE or CE in oxygen radical antioxidant capacity assays. In HUVECs, VCEC significantly suppressed increases in the production of intracellular reactive oxygen species, decreased levels of nitric oxide and vascular endothelial-cadherin, and increased endothelial hyperpermeability triggered by H₂O₂. Treatment with VE or CE alone ameliorated HUVEC injury in a pattern similar to VCEC, although their effects were significantly weaker than VCEC. Overall, VCEC exhibited a substantial synergistic effect on protecting endothelial cells against oxidative damage through its antioxidant activity. Therefore, VCEC could be developed as a potential agent for reducing the risk of vascular diseases related to oxidative stress.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (67)
참고문헌 신청
Alexander JS / 2000 / Inflammatory mediators induce sequestration of VE-cadherin in cultured human endothelial cells / Inflammation 24:99~113
Banerjee J / 2019 / Redox control of vascular biology / Oxid Med Cell Longev 2019:3764252
Benmeziane F / 2016 / Determination of major anthocyanin pigments and flavonols in red grape skin of some table grape varieties (Vitis vinifera sp.) by high-performance liquid chromatography-photodiode array detection (HPLC-DAD) / OENO One 50:125~135
Bian D / 2012 / Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress / J Biochem Mol Toxicol 26:399~406
Bogatcheva NV / 2003 / Mitogen-activated protein kinases in endothelial pathophysiology / J Investig Med 51:341~352
Banerjee J / 2019 / Redox control of vascular biology / Oxid Med Cell Longev 2019:3764252
Benmeziane F / 2016 / Determination of major anthocyanin pigments and flavonols in red grape skin of some table grape varieties (Vitis vinifera sp.) by high-performance liquid chromatography-photodiode array detection (HPLC-DAD) / OENO One 50:125~135
Bian D / 2012 / Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress / J Biochem Mol Toxicol 26:399~406
Bogatcheva NV / 2003 / Mitogen-activated protein kinases in endothelial pathophysiology / J Investig Med 51:341~352
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UCI(KEPA) : I410-ECN-0101-2020-594-000846890