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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 조선대학교 의학연구원 Medical Biological Science and Engineering Medical Bilogical Science and Engineering Vol.7 No.1
- 발행연도
- 2024.1
- 수록면
- 28 - 34 (7page)
- DOI
- 10.30579/mbse.2024.7.1.28
이용수
초록· 키워드
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In this study, we observed the inhibition of lipopolysaccharide (LPS)-stimulated shape changes in mouse macrophages by grape seed extract (GSE). Upon stimulation with LPS, macrophages typically exhibited pseudopodia formation, including lamellipodia and filopodia, along with an increase in size; meanwhile, unstimulated cells maintained their round morphology. GSE effec tively impeded these LPS-induced morphological changes and phagocytosis. To investigate the mechanisms of the inhibitory action of GSE on macrophage activation, we investigated its im pact on mitogen-activated protein kinase (MAPK). Although GSE did not significantly inhibit JNK, one of the three MAPK family members, it exerted notable inhibitory effects on p38 and ERK1/2.
In summary, GSE demonstrated potent efficacy in restraining both phagocytosis and morpho logical transformation of macrophages. Given the centrality of these kinases in inflammatory signals, GSE has emerged as a promising candidate for anti-inflammatory interventions.
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