Do All Antioxidant Supplements Have the Same Potential Effect on Preventing Myringosclerosis?

Seden Akdagli; Arzu Tuzuner; Sule Demirci; Hatice Karadas; Kamil Gokce Tulaci; Mehmet Dogan; Refik Caylan

추천

검색

자료유형: 학술저널

저자정보: Seden Akdagli Arzu Tuzuner Sule Demirci Hatice Karadas Kamil Gokce Tulaci Mehmet Dogan Refik Caylan

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제8권 제1호

발행연도: 2015.1

수록면: 1 - 6 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives. Myringosclerosis is an irreversible pathological healing mechanism of the tympanic membrane which can result in the formation of sclerotic plaques. Antioxidant treatment is a recognised prevention therapy and coenzyme Q10 (CoQ10), lycopene, and grape seed extract (GSE), were used in this manner. Methods. Forty-four Wistar rats were used in this experiment, and, following myringotomies, the animals were randomly divided into four groups. CoQ10, lycopene or GSE was administered orally to the respective groups, starting from the day of surgery. Otomicroscopy examination was performed on the 14th day. All tympanic membrane lesions were evaluated and compared otomicroscopically and histopathologically. Results. The otomicroscopy and histopathological findings, compared against a control (saline) group, showed the CoQ10, lycopene, and GSE groups had statistically significant differences of degree of sclerosis (P<0.001). Conclusion. CoQ10, lycopene, and GSE were compared against a saline group and their antioxidative and anti-inflammatory effects were similar. The formation of myringosclerotic plagues after experimental myringotomy in rats significantly decreased and diminished after systemic administration of the three different antioxidant supplements.

#Myringosclerosis #Grape Seed Extract #Lycopene #Coenzyme Q10 #Antioxidant

참고문헌 (20)

참고문헌 신청

Ann Otol Rhinol Laryngol. / 1997 / Application of oxygen free radical scavengers to diminish the occurrence of myringosclerosis / Ann Otol Rhinol Laryngol 106 (6) : 513 ~ 51

Bagchi D / 1997 / Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro / Res Commun Mol Pathol Pharmacol 95 (2) :

Bentinger M / 2007 / The antioxidant role of coenzyme Q / mitochondrion 7 (Suppl) : S41 ~ S50

Beyer RE / 1992 / An analysis of the role of coenzyme Q in free radical generation and as an antioxidant / Biochem Cell Biol 70 (6) : 390 ~ 403

Bhaya MH / 1993 / Pathogenesis of tympanosclerosis / Otolaryngol Head Neck Surg 109 (3 Pt 1) : 413 ~ 420

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!