지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.3
- 수록면
- 155 - 163 (9page)
- DOI
- 10.3343/alm.2023.0212
이용수
초록· 키워드
오류제보하기
Background: Echinococcosis is a neglected tropical disease that is severely underdiag- nosed in resource-limited settings. In developed countries, diagnosing echinococcosis is challenging, and reliable serological assays are urgently needed. In the Central European Alps, EM is more common than EG; however, data on the diagnostic performance of as- says for EM cases are scarce. We evaluated the suitability of nine antibody assays for rou- tine diagnostics.
Methods: Nine commercially available serological assays for detecting anti-Echinococcus antibodies were compared head-to-head using samples collected from 50 patients with echinococcosis and 50 age- and sex-matched control subjects. The assays are Anti-Echi- nococcus ELISA (IgG) (Euroimmun), Echinococcus IgG ELISA (DRG), Echinococcus IgG ELISA (IBL International), Echinococcus Western Blot IgG (LDBIO Diagnostics), EUROLINE WB (Euroimmun), Hydatidosis ELISA IgG (VirCell), Hydatidosis VIRCLIA IgG Monotest (Vir- Cell), Ridascreen Echinococcus IgG (R-Biopharm), and Virapid Hydatidosis (VirCell). The cases were ranked according to the WHO-Informal Working Group on Echinococcosis (WHO-IWGE) criteria as confirmed, probable, or possible.
Results: The performance of the assays varied greatly, with overall sensitivities ranging be- tween 50% and 88% and specificities between 62% and 100%. We observed a trend to- ward better performance with cases classified as “confirmed” using the WHO-IWGE crite- ria. Combined analysis with sequential screening and confirmatory testing resulted in a maximum sensitivity of 84% and specificity of 100%. Differentiation between EG and EM infections is clinically relevant but was found to be unreliable.
Conclusions: Echinococcus serological assays are highly variable in terms of sensitivity and specificity. Knowledge of the pre-test probability in the patient cohort is required to choose a suitable assay. A combined approach with screening and confirmatory assays may be the best diagnostic strategy in many situations.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genotypes of Echinococcus Species from Cattle in Tanzania
Parasites, Hosts and Diseases
2021 .10
-
Prevalence of Serum IgG Antibodies to Cystic Echinococcus Antigen among Patients in an Uzbekistan Emergency Hospital
Parasites, Hosts and Diseases
2015 .12
-
Practical Algorisms for PCR-RFLP-Based Genotyping of Echinococcus granulosus Sensu Lato
Parasites, Hosts and Diseases
2017 .12
-
Phylogenetic Characteristics of Echinococcus granulosus Sensu Lato in Uzbekistan
Parasites, Hosts and Diseases
2020 .04
-
Prevalence and Molecular Characterization of Echinococcus granulosus Sensu Stricto in Northern Xinjiang, China
Parasites, Hosts and Diseases
2019 .04
-
Environmental Contamination by Echinococcus granulosus sensu lato Eggs in Relation to Slaughterhouses in Urban and Rural Areas in Tunisia
Parasites, Hosts and Diseases
2016 .02
-
A Rapid and Convenient Method for in Vivo Fluorescent Imaging of Protoscolices of Echinococcus multilocularis
Parasites, Hosts and Diseases
2016 .04
-
Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus
Parasites, Hosts and Diseases
2016 .10
-
Two Human Cases of Echinococcus ortleppi Infection in the Lung and Heart in Vietnam
Parasites, Hosts and Diseases
2020 .08
-
Construction of In Vivo Fluorescent Imaging of Echinococcus granulosus in a Mouse Model
Parasites, Hosts and Diseases
2016 .06
-
Unusual Location of Hydatid Cysts : Report of Two Cases in the Heart and Hip Joint of Romanian Patients
Parasites, Hosts and Diseases
2017 .08
-
Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process
Parasites, Hosts and Diseases
2020 .06
-
A Case of Alveolar Echinococcosis Occurring in the Hilar Bile Duct
Parasites, Hosts and Diseases
2019 .10
-
A Case of Human Hepatic Alveolar Echinococcosis Accompanied by Lung and Brain Metastases
Parasites, Hosts and Diseases
2021 .06
-
Analysis of Lethality in Echinococcal Disease
Parasites, Hosts and Diseases
2017 .10
-
Genetic Diversity of Echinococcus granulosus Genotype G1 in Xinjiang, Northwest of China
Parasites, Hosts and Diseases
2018 .08
-
Molecular Cloning and Characterization of a P38-Like Mitogen-Activated Protein Kinase from Echinococcus granulosus
Parasites, Hosts and Diseases
2016 .12
-
Echinococcus granulosus Protoscolex DM9 Protein Shows High Potential for Serodiagnosis of Alveolar Echinococcosis
Parasites, Hosts and Diseases
2022 .02
-
Proteomic Analysis on Exosomes Derived from Patients’ Sera Infected with Echinococcus granulosus
Parasites, Hosts and Diseases
2019 .10
-
Performance Comparison of Five SARS-CoV-2 Antibody Assays for Seroprevalence Studies
Annals of Laboratory Medicine
2022 .01
최근 본 자료
댓글(0)
0