Proteomic Analysis on Exosomes Derived from Patients' Sera Infected with Echinococcus granulosus

Wen Wang; Xiaojing Zhou; Fang Cui; Chunli Shi; Yulan Wang; Yanfei Men; Wei Zhao; Jiaqing Zhao

추천

검색

질문

자료유형: 학술저널

저자정보: Wen Wang (Ningxia Medical University) Xiaojing Zhou (Ningxia Medical University) Fang Cui (Ningxia Medical University) Chunli Shi (Ningxia Medical University) Yulan Wang (Ningxia Medical University) Yanfei Men (Ningxia Medical University) Wei Zhao (Ningxia Medical University) Jiaqing Zhao (Ningxia Medical University)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.57 No.5

발행연도: 2019.10

수록면: 489 - 497 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Cystic echinococcosis (CE), a zoonotic disease caused by Echinococcus granulosus at the larval stage, predominantly develops in the liver and lungs of intermediate hosts and eventually results in organ malfunction or even death. The interaction between E. granulosus and human body is incompletely understood. Exosomes are nanosized particles ubiquitously present in human body fluids. Exosomes carry biomolecules that facilitate communication between cells. To the best of our knowledge, the role of exosomes in patients with CE is not reported. Here, we isolated exosomes from the sera of patients with CE (CE-exo) and healthy donors and subjected them to liquid chromatography-tandem mass spectrometry analysis. Proteomic analysis identified 49 proteins specifically expressed in CE-exo, including 4 proteins of parasitic origin. The most valuable parasitic proteins included tubulin alpha-1C chain and histone H4. And 8 proteins were differentially regulated in CE-exo (fold change>1.5), as analyzed with bioinformatic methods such as annotation and functional enrichment analyses. These findings may improve our understanding about the interaction between E. granulosus and human body, and may contribute to the diagnosis and prevention of CE.

#Exosome #cystic echinococcosis #proteomic #gene ontology

참고문헌 (44)

참고문헌 신청

Bold B / 2018 / Patients with cystic echinococcosis in the three national referral centers of Mongolia : A model for CE management assessment / PLoS Negl Trop Dis 12:e0006686

Larrieu E / 2019 / Epidemiology, diagnosis, treatment and follow-up of cystic echinococcosis in asymptomatic carriers / Trans R Soc Trop Med Hyg 113:74~80

Liu C / 2015 / In vivo and in vitro efficacies of mebendazole, mefloquine and nitazoxanide against cyst echinococcosis / Parasitol Res 114:2213~2222

Smego RJ Jr / 2005 / Treatment options for hepatic cystic echinococcosis / Int J Infect Dis 9:69~76

Riganò R1 / 2001 / Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses / Infect Immun 69:288~296

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!