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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 604 - 612 (9page)
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Purpose: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis.
Materials and Methods: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7.
Results: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidenceinterval (CI)= 2.58–144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00–2.68, p=0.048) were associated with recovery of AKI.
Conclusion: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.
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참고문헌 (34)
참고문헌 신청
Cruz DN / 2011 / Biomarker strategies to predict need for renal replacement therapy in acute kidney injury / Semin Dial 24:124~131
Ahlström A / 2004 / Evolution and predictive power of serum cystatin C in acute renal failure / Clin Nephrol 62:344~350
Zhang Z / 2011 / Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis / Am J Kidney Dis 58:356~365
Di Nardo M / 2013 / Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: an observational study / Blood Purif 35:172~176
Dai X / 2015 / Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury / Crit Care 19:223
Ahlström A / 2004 / Evolution and predictive power of serum cystatin C in acute renal failure / Clin Nephrol 62:344~350
Zhang Z / 2011 / Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis / Am J Kidney Dis 58:356~365
Di Nardo M / 2013 / Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: an observational study / Blood Purif 35:172~176
Dai X / 2015 / Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury / Crit Care 19:223
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