지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.2
- 수록면
- 164 - 175 (12page)
- DOI
- https://doi.org/10.3803/EnM.2023.1792
이용수
초록· 키워드
오류제보하기
Background: Delayed postoperative hyponatremia (DPH) is the most common cause of readmission after pituitary surgery. In this study, we aimed to evaluate the cutoff values of serum copeptin and determine the optimal timing for copeptin measurement for the prediction of the occurrence of DPH in patients who undergo endoscopic transsphenoidal approach (eTSA) surgery and tumor resection.
Methods: This was a prospective observational study of 73 patients who underwent eTSA surgery for pituitary or stalk lesions. Copeptin levels were measured before surgery, 1 hour after extubation, and on postoperative days 1, 2, 7, and 90.
Results: Among 73 patients, 23 patients (31.5%) developed DPH. The baseline ratio of copeptin to serum sodium level showed the highest predictive performance (area under the curve [AUROC], 0.699), and its optimal cutoff to maximize Youden’s index was 2.5×10–11, with a sensitivity of 91.3% and negative predictive value of 92.0%. No significant predictors were identified for patients with transient arginine vasopressin (AVP) deficiency. However, for patients without transient AVP deficiency, the copeptin-to-urine osmolarity ratio at baseline demonstrated the highest predictive performance (AUROC, 0.725). An optimal cutoff of 6.5×10–12 maximized Youden’s index, with a sensitivity of 92.9% and a negative predictive value of 94.1%.
Conclusion: The occurrence of DPH can be predicted using baseline copeptin and its ratio with serum sodium or urine osmolarity only in patients without transient AVP deficiency after pituitary surgery.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Association between copeptin levels and treatment responses to hypertonic saline infusion in patients with symptomatic hyponatremia: a prospective cohort study
Kidney Research and Clinical Practice
2021 .09
-
A novel role of copeptin as a biomarker for the prediction of treatment response in hyponatremia
Kidney Research and Clinical Practice
2021 .09
-
Serum Copeptin Levels Predict Clinical Outcomes After Successful Percutaneous Coronary Intervention in Patients With Acute Myocardial Infarction
Annals of Laboratory Medicine
2018 .01
-
Copeptin in Hemodialysis Patients with Left Ventricular Dysfunction
Yonsei Medical Journal
2015 .01
-
Serum copeptin as a predictor of risk of hyponatremia after transurethral prostatectomy
Kidney Research and Clinical Practice
2023 .03
-
The Relationship between Ghrelin and Copeptin Levels, and Anxiety and Depression Levels in Suicide Attempts
Clinical Psychopharmacology and Neuroscience
2017 .08
-
Performance of Copeptin for Early Diagnosis of Acute Myocardial Infarction in an Emergency Department Setting
Annals of Laboratory Medicine
2020 .01
-
The Anti-Inflammatory Effect of Arginine-Vasopressin on Lipopolysaccharide-Induced IκBα/Nuclear Factor-κB Cascade
Acute and Critical Care
2015 .01
-
Evaluation of Copeptin for Diagnosing Non-ST Segment Elevation Acute Myocardial Infarction in Patients with Chest pain and Mild Troponin I Elevation
Laboratory Medicine Online
2022 .01
-
Copeptin with high-sensitivity troponin at presentation is not inferior to serial troponin measurements for ruling out acute myocardial infarction
Clinical and Experimental Emergency Medicine
2020 .01
-
Assessment of brain natriuretic peptide and copeptin as correlates of blood pressure in chronic hypertensive pregnant women
Clinical Hypertension
2022 .01
-
Delayed diagnosis of pituitary stalk interruption syndrome with severe recurrent hyponatremia caused by adrenal insufficiency
Annals of Pediatirc Endocrinology & Metabolism
2017 .01
-
New insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidus
Kidney Research and Clinical Practice
2019 .01
-
The influence of pituitary volume on the growth response in growth hormone-treated children with growth hormone deficiency or idiopathic short stature
Annals of Pediatirc Endocrinology & Metabolism
2024 .04
-
Heart Rate Variability in Postoperative Patients with Nonfunctioning Pituitary Adenoma
Endocrinology and Metabolism
2021 .01
-
Validation of Simultaneous Endoscopic Sinus Surgery and Transsphenoidal Surgery in Patients with Chronic Rhinosinusitis and Pituitary Tumors
대한이비인후-두경부외과학회지
2020 .01
-
The Predictive Value of Pathologic Features in Pituitary Adenoma and Correlation with Pituitary Adenoma Recurrence
Journal of Pathology and Translational Medicine
2016 .01
-
Mineral deficiencies
대한외과학회 학술대회 초록집
2016 .11
-
Risk factors for overcorrection of severe hyponatremia: a post hoc analysis of the SALSA trial
Kidney Research and Clinical Practice
2022 .06
-
Rare Frequency of Mutations in Pituitary Transcription Factor Genes in Combined Pituitary Hormone or Isolated Growth Hormone Deficiencies in Korea
Yonsei Medical Journal
2017 .01
최근 본 자료
댓글(0)
0