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논문 기본 정보

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학술저널
저자정보
양희진 (Hallym University Dongtan Sacred Heart Hospital Hwaseong Republic of Korea) Yoon Songuk (Hallym University Dongtan Sacred Heart Hospital) Kim Eun Jung (Hallym University Dongtan Sacred Heart Hospital) 서장원 (Hallym University Dongtan Sacred Heart Hospital Hwaseong Republic of Korea) 구자룡 (한림대학교) Oh Yun Kyu (Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Med) Jo You Hwan (Department of Emergency Medicine Seoul National University Bundang Hospital Seongnam Korea.) Kim Sejoong (Seoul National University Bundang Hospital) Baek Seon Ha (Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital Hwaseong Republic o)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.41 No.3
발행연도
2022.6
수록면
298 - 309 (12page)
DOI
10.23876/j.krcp.21.180

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Background: Hyponatremia overcorrection can result in irreversible neurologic impairment such as osmotic demyelination syndrome. Few prospective studies have identified patients undergoing hypertonic saline treatment with a high risk of hyponatremia overcorrection. Methods: We conducted a post hoc analysis of a multicenter, prospective randomized controlled study, the SALSA trial, in 178 patients aged above 18 years with symptomatic hyponatremia (mean age, 73.1 years; mean serum sodium level, 118.2 mEq/L). Overcorrection was defined as an increase in serum sodium levels by >12 or 18 mEq/L within 24 or 48 hours, respectively. Results: Among the 178 patients, 37 experienced hyponatremia overcorrection (20.8%), which was independently associated with initial serum sodium level (≤110, 110?115, 115?120, and 120?125 mEq/L with 7, 4, 2, and 0 points, respectively), chronic alcoholism (7 points), severe symptoms of hyponatremia (3 points), and initial potassium level (<3.0 mEq/L, 3 points). The NASK (hypoNatremia, Alcoholism, Severe symptoms, and hypoKalemia) score was derived from four risk factors for hyponatremia overcorrection and was significantly associated with overcorrection (odds ratio, 1.41; 95% confidence interval, 1.24?1.61; p < 0.01) with good discrimination (area under the receiver-operating characteristic [AUROC] curve, 0.76; 95% CI, 0.66?0.85; p < 0.01). The AUROC curve of the NASK score was statistically better compared with those of each risk factor. Conclusion: In treating patients with symptomatic hyponatremia, individuals with high hyponatremia overcorrection risks were predictable using a novel risk score summarizing baseline information.

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